Department of Fetal-Maternal Medicine and Gynecology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
Department of Environmental Epidemiology, Institute of Occupational Medicine, Lodz, Poland.
Epidemiol Infect. 2014 Mar;142(3):656-61. doi: 10.1017/S0950268813001179. Epub 2013 May 31.
This study aimed to describe Toxoplasma gondii prevalence in Polish pregnant women and the incidence rates of congenital infections in their neonates observed between 2004 and 2012. Serological tests for T. gondii-specific IgG and IgM antibodies were performed on serum samples of 8281 pregnant women treated at the Polish Mother's Memorial Hospital Research Institute in Lodz. The yearly seroconversion rate for T. gondii IgG antibodies was estimated using a mathematical model to determine the dependency between age and prevalence. Mean prevalence of IgG antibodies between 2004 and 2012 in pregnant women was 40·6% [95% confidence interval (CI) 39·6-41·7] and increased with age with a yearly seroconversion rate of 0·8% (95% CI 0·6-1·0, P<0·001). Assuming a T. gondii materno-fetal transmission rate of 30% gave an estimate of 1·80/1000 neonates as congenitally infected. The increased mean age (28·7 vs 26·7 years, P<0·001) of pregnant women was probably the most important factor in abolishing the effect of falling prevalence rates.
本研究旨在描述 2004 年至 2012 年间波兰孕妇中弓形虫的流行情况以及其新生儿先天性感染的发生率。在罗兹波兰母亲纪念医院研究所，对 8281 名接受治疗的孕妇的血清样本进行了针对弓形虫特异性 IgG 和 IgM 抗体的血清学检测。使用数学模型估计了 T. gondii IgG 抗体的年血清转化率，以确定年龄与流行率之间的关系。2004 年至 2012 年期间，孕妇 IgG 抗体的平均流行率为 40.6%（95%CI 39.6-41.7），并随年龄增长而增加，年血清转化率为 0.8%（95%CI 0.6-1.0，P<0.001）。假设 30%的 T. gondii 母婴传播率，则估计有 1.80/1000 名新生儿为先天性感染。孕妇平均年龄（28.7 岁比 26.7 岁，P<0.001）的增加可能是消除流行率下降影响的最重要因素。
