基于料仓式滤波器互补金属氧化物半导体图像传感器的片上荧光显微镜。
Chip-scale fluorescence microscope based on a silo-filter complementary metal-oxide semiconductor image sensor.
机构信息
Department of Electrical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
出版信息
Opt Lett. 2013 Jun 1;38(11):1817-9. doi: 10.1364/OL.38.001817.
Abstract
We demonstrate a silo-filter (SF) complementary metal-oxide semiconductor (CMOS) image sensor for a chip-scale fluorescence microscope. The extruded pixel design with metal walls between neighboring pixels guides fluorescence emission through the thick absorptive filter to the photodiode of a pixel. Our prototype device achieves 13 μm resolution over a wide field of view (4.8 mm × 4.4 mm). We demonstrate bright-field and fluorescence longitudinal imaging of living cells in a compact, low-cost configuration.
摘要
我们展示了一种用于片上荧光显微镜的筒式滤光片（SF）互补金属氧化物半导体（CMOS）图像传感器。具有金属壁的挤出像素设计可引导荧光发射穿过厚吸收滤光片到达像素的光电二极管。我们的原型器件在宽视场（4.8mm×4.4mm）上实现了 13μm 的分辨率。我们展示了在紧凑、低成本配置下对活细胞进行明场和荧光纵向成像的能力。
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