小儿被动吸烟与食管炎之间存在关联吗？
Is There any Association Between Passive Smoking and Esophagitis in Pediatrics?
作者信息
Monajemzadeh Maryam, Haghi-Ashtiani Mohammad-Taghi, Soleymani Roohallah, Shams Sedigheh, Taleb Shayandokht, Motamed Farzaneh, Najafi Mehri, Abbasi Ata
机构信息
Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran ; Children's Medical Center, Pediatric Center of Excellence, Tehran, Iran ; Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Iran J Pediatr. 2013 Apr;23(2):194-8.
OBJECTIVE
Exposure to environmental tobacco smoke (ETS) is one of the major factors of predisposing children to develop several hazardous health problems. We decided to investigate the association between nicotinine, one of the nicotine metabolites and esophagitis in children with gastroesophageal reflux disease (GERD).
METHODS
In a case control study 46 children suffering from esophagitis referred to endoscopy ward were recruited. The control group consisted of 45 healthy children. Urine samples were collected and urinary cotinine level (UCL) measured.
FINDINGS
The mean age of esophagitis and control groups were 5.11±2.93 and 6.72±2.8 respectively. Sixty children were passive smokers; 31 of them had non-smoker parents. In control group, 32 (71.1%) children and in esophagitis group 29 (63%) children had non-smoker parents. The mean value of UCL in patients suffering from esophagitis was significantly higher than those in normal group (P=0.04, 24.98±6.4 ng/ml vs. 15.16 ± 3.9 ng/ml). Considering 50ng/ml as a cutoff point for UCL, it was significantly higher in passive smoker group than in non smoker group (P=0.02). The mean cotinine level differed significantly in esophagitis and control group.
CONCLUSION
Our results indicate the increased risk of developing esophagitis in children with ETS exposure.
目的
接触环境烟草烟雾（ETS）是儿童易患多种有害健康问题的主要因素之一。我们决定研究烟碱（尼古丁代谢物之一）与胃食管反流病（GERD）患儿食管炎之间的关联。
方法
在一项病例对照研究中，招募了46名转诊至内镜病房的食管炎患儿。对照组由45名健康儿童组成。收集尿液样本并测量尿可替宁水平（UCL）。
结果
食管炎组和对照组的平均年龄分别为5.11±2.93岁和6.72±2.8岁。60名儿童为被动吸烟者；其中31名儿童的父母不吸烟。在对照组中，32名（71.1%）儿童和食管炎组中29名（63%）儿童的父母不吸烟。食管炎患儿的UCL平均值显著高于正常组（P = 0.04，24.98±6.4 ng/ml对15.16±3.9 ng/ml）。将50ng/ml作为UCL的临界值，被动吸烟组显著高于非吸烟组（P = 0.02）。食管炎组和对照组的可替宁平均水平差异显著。
结论
我们的结果表明，接触ETS的儿童患食管炎的风险增加。
Zotero 插件