澳大利亚韦尼克-科尔萨科夫综合征的患病率：硫胺素强化是否起到了作用？
Prevalence of Wernicke-Korsakoff syndrome in Australia: has thiamine fortification made a difference?
作者信息
Harper C G, Sheedy D L, Lara A I, Garrick T M, Hilton J M, Raisanen J
机构信息
Department of Pathology, University of Sydney, NSW.
出版信息
Med J Aust. 1998 Jun 1;168(11):542-5. doi: 10.5694/j.1326-5377.1998.tb139081.x.
OBJECTIVE
To determine the prevalence of the Wernicke-Korsakoff syndrome (WKS) in Australia and compare this with previous studies.
DESIGN AND SETTING
Prospective autopsy study at the New South Wales Institute of Forensic Medicine, 1996-1997.
METHODS
Brains of deceased people (aged over 15 years) derived from 2212 sequential autopsies performed between 1 January 1996 and 31 December 1997 were studied macroscopically and microscopically to identify cases of WKS.
MAIN OUTCOME MEASURES
Standard histological criteria for WKS and any available clinical data.
RESULTS
Twenty-five cases of WKS were identified (prevalence, 1.1%), mostly among the 5.9% of the 2212 people who had a history suggestive of alcohol abuse. Only four cases (16%) had been diagnosed during life.
CONCLUSIONS
There has been a significant reduction in the prevalence of WKS in Australia since the introduction of thiamine enrichment of bread flour. While the prevalence is still higher than in most other Western countries, further research is needed before adding thiamine to alcoholic beverages can be recommended.
目的
确定澳大利亚韦尼克 - 科萨科夫综合征（WKS）的患病率，并与之前的研究进行比较。
设计与地点
1996 - 1997年在新南威尔士法医研究所进行的前瞻性尸检研究。
方法
对1996年1月1日至1997年12月31日期间连续进行的2212例尸检（死者年龄超过15岁）的大脑进行宏观和微观研究，以确定WKS病例。
主要观察指标
WKS的标准组织学标准及任何可用的临床数据。
结果
共鉴定出25例WKS病例（患病率为1.1%），大多在有酗酒史的2212人中的5.9%里。生前仅诊断出4例（16%）。
结论
自面包粉添加硫胺素以来，澳大利亚WKS的患病率显著下降。虽然该患病率仍高于大多数其他西方国家，但在建议在酒精饮料中添加硫胺素之前，还需要进一步研究。
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