Unluer A N, Findik R B, Sevinc N, Karakaya J
Department of Obstetrics and Gynecology, Bilecik Central Hospital, Bilecik, Turkey.
Clin Exp Obstet Gynecol. 2013;40(1):148-50.
To compare obese and non-obese polycystic ovary syndrome (PCOS) patients with respect to lipid profile, hormone profiles, and hemoglobin A1c (HbA1c) values indicating chronic hyperglicemia.
Thirty PCOS patients with a body mass index (BMI) > 25 and 35 non-obese PCOS patients with BMI < 25 were compared with regard to basal luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), estradiol (E2), fasting blood sugar (FBS), low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TCOL), triglyceride (TG), and HbA1c values.
HDL value (p = 0.005) was significantly higher in non-obese group while TG (p = 0.001) was higher in the obese group. No significant difference was found between other values.
Lipid metabolism impairment seems to be more marked in obese PCOS patients. Moreover, it is obvious that insulin resistance is higher in obese group. The absent difference between obese and non-obese groups in terms of HbA1c values suggests that insulin resistance occurring in the obese group may also be important in the non-obese group. In this context, cardiovascular risks may increase in non-obese PCOS patients.
比较肥胖和非肥胖多囊卵巢综合征（PCOS）患者的血脂谱、激素谱以及提示慢性高血糖的糖化血红蛋白（HbA1c）值。
比较30例体重指数（BMI）>25的PCOS患者和35例BMI<25的非肥胖PCOS患者的基础促黄体生成素（LH）、促卵泡生成素（FSH）、催乳素（PRL）、雌二醇（E2）、空腹血糖（FBS）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、总胆固醇（TCOL）、甘油三酯（TG）和HbA1c值。
非肥胖组的HDL值（p = 0.005）显著更高，而肥胖组的TG值（p = 0.001）更高。其他值之间未发现显著差异。
肥胖的PCOS患者脂质代谢损害似乎更明显。此外，肥胖组的胰岛素抵抗明显更高。肥胖组和非肥胖组在HbA1c值方面没有差异，这表明肥胖组出现的胰岛素抵抗在非肥胖组中可能也很重要。在这种情况下，非肥胖PCOS患者的心血管风险可能会增加。
