Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Arch Iran Med. 2013 Jun;16(6):369-70.
Squamous cell carcinoma (SCC) of the pancreas is a controversial entity of uncertain origin, as the pancreas is entirely devoid of squamous cells. Cases of pancreatic carcinomas that exhibit primary squamous morphology are rarely described in the literature. We report a case of primary SCC of the pancreas in a 66-year-old woman with complaints of epigastric pain of five months duration. Imaging studies demonstrated a solid tumor in the body of the pancreas that invaded the superior mesenteric (SMA) and celiac arteries, as well as regional lymph nodes. Cytological examination of an endosonography-guided fine needle aspiration (EUS-FNA) specimen confirmed the diagnosis of well-differentiated SCC of the pancreas. On the basis of diagnosis and examinations prior to chemotherapy, we did not detect any SCC lesions that might have metastasized to the pancreas. Primary SCC of the pancreas is a rare entity that comprises 0.05% of all exocrine pancreatic carcinomas. The clinical profile and biological behavior of pancreas SCC are similar to typical pancreatic ductal adenocarcinomas.
胰腺鳞状细胞癌（SCC）是一种起源不明的有争议实体，因为胰腺完全没有鳞状细胞。文献中很少描述表现出原发性鳞状形态的胰腺癌病例。我们报告了一例 66 岁女性的胰腺原发性 SCC，其主要症状为五个月的上腹痛。影像学研究显示胰腺体部有一实性肿瘤，侵犯肠系膜上动脉（SMA）和腹腔动脉，以及局部淋巴结。超声内镜引导下细针抽吸（EUS-FNA）标本的细胞学检查证实了胰腺分化良好的 SCC 诊断。根据化疗前的诊断和检查，我们未发现可能转移至胰腺的 SCC 病变。胰腺原发性 SCC 较为罕见，占所有外分泌胰腺腺癌的 0.05%。胰腺 SCC 的临床特征和生物学行为与典型的胰腺导管腺癌相似。
