Nutritional Epidemiology Observatory, Josué de Castro Nutrition Institute, Rio de Janeiro Federal University, Rio de Janeiro, Brazil.
J Affect Disord. 2014 Jan;152-154:76-82. doi: 10.1016/j.jad.2013.04.045. Epub 2013 May 31.
To estimate the prevalence of suicide risk (SR) and major depressive episodes (MDEs) in early pregnancy, as well as the relationship of serum fatty acid status to these outcomes.
Cross-sectional analyses were performed on data from 234 pregnant women enrolled in a prospective cohort study in Rio de Janeiro, Brazil. SR and MDE were defined according to the Mini International Neuropsychiatric Interview. Fatty acid compositions were determined for serum samples obtained between the 6th and 13th gestational week. Fatty acid data were expressed as the percent of total fatty acids, converted to Z scores and then entered as continuous variables in logistic regression models.
The prevalence of SR was 19.6% and that of MDE was 17.0%. In the adjusted logistic regressions, a higher likelihood of SR was observed among women with higher arachidonic acid levels [AA (20:4, n-6): OR=1.45, 95%CI 1.02-2.07] and adrenic acid levels [AdA (22:4, n-6): OR=1.43, 95%CI 1.01-2.04]. A higher likelihood of MDE was also observed among women with higher AA levels [OR=1.47, 95%CI 1.03-2.10] and AdA levels [OR=1.59, 95%CI 1.09-2.32].
Higher serum levels of AA and AdA were associated with a greater likelihood of SR and MDE among pregnant Brazilian women.
评估妊娠早期自杀风险（SR）和重度抑郁发作（MDE）的患病率，以及血清脂肪酸状况与这些结果的关系。
对巴西里约热内卢一项前瞻性队列研究中招募的 234 名孕妇的数据进行了横断面分析。根据 Mini 国际神经精神访谈（Mini International Neuropsychiatric Interview）定义了 SR 和 MDE。在妊娠第 6 至 13 周之间采集血清样本，测定脂肪酸组成。脂肪酸数据表示为总脂肪酸的百分比，转换为 Z 分数，然后作为连续变量输入逻辑回归模型。
SR 的患病率为 19.6%，MDE 的患病率为 17.0%。在调整后的逻辑回归中，AA（20:4，n-6）水平较高的女性发生 SR 的可能性更高[比值比（OR）=1.45，95%可信区间（CI）1.02-2.07]，AdA（22:4，n-6）水平较高的女性发生 SR 的可能性也更高[OR=1.43，95%CI 1.01-2.04]。AA 水平较高的女性发生 MDE 的可能性也更高[OR=1.47，95%CI 1.03-2.10]，AdA 水平较高的女性发生 MDE 的可能性也更高[OR=1.59，95%CI 1.09-2.32]。
较高的血清 AA 和 AdA 水平与巴西孕妇发生 SR 和 MDE 的可能性增加相关。
