Department of Respiratory Medicine, Galway University Hospitals, Newcastle Road, Galway, Ireland.
QJM. 2013 Aug;106(8):709-15. doi: 10.1093/qjmed/hct109. Epub 2013 May 30.
Bronchiectasis is a chronic debilitating condition with considerable phenotypic diversity. A vicious cycle of infection and inflammation exists in damaged airways with patients suffering from persistent cough, purulent sputum production, recurrent chest infections and general malaise. The associated burden of disease in terms of increased morbidity, reduced quality of life and the socioeconomic cost of long-term management is significant. Further research is essential to improve our understanding of the development and progression of this disease. This article reviews what is currently known about bronchiectasis, its pathophysiology, aetiology and management strategies.
支气管扩张症是一种慢性消耗性疾病，具有相当大的表型多样性。在受损的气道中存在感染和炎症的恶性循环，患者会持续咳嗽、咳出脓性痰、反复发生胸部感染和全身不适。该病的疾病负担增加，包括发病率升高、生活质量下降以及长期管理的社会经济成本，这是非常显著的。进一步的研究对于提高我们对这种疾病的发展和进展的理解至关重要。本文综述了目前对支气管扩张症的认识，包括其病理生理学、病因学和管理策略。
