Borekci Sermin, Halis Ayse Nigar, Aygun Gokhan, Musellim Benan
Department of Pulmonary Diseases, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
Department of Microbiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
Ann Thorac Med. 2016 Jan-Mar;11(1):55-9. doi: 10.4103/1817-1737.172297.
To evaluate the bacterial colonization and associated risk factors in patients with bronchiectasis.
A total of 121 patients followed at the Bronchiectasis Unit, between 1996 and 2013 and diagnosed as having noncystic fibrosis bronchiectasis with high resolution computed tomography or multi-slice computed tomography were included in this retrospective study. The following definition of colonization was used for study purposes: Detection of at least two isolates of an organism separated by at least 3 months in a year.
Of these 121 patients, 65 (54%) were female and 56 (46%) were male. Mean age was 50.6 ± 16.1 years. Mean duration of illness was 20.3 ± 15.5 years. 43 (35.5%) cases had colonization. The major pathogens responsible for colonization were Pseudomonas aeruginosa (n = 25; 20.6%) and Haemophilus influenzae (n = 14, 11.5%). The stepwise logistic regression analysis showed a significant association between colonization and a low percentage of forced vital capacity (FVC%) and the presence of cystic bronchiectasis (P < 0.05).
The following factors have been found to be associated with colonization in patients with bronchiectasis: Low FVC% and the presence of cystic bronchiectasis.
评估支气管扩张症患者的细菌定植情况及相关危险因素。
本回顾性研究纳入了1996年至2013年间在支气管扩张症科室就诊，经高分辨率计算机断层扫描或多层计算机断层扫描诊断为非囊性纤维化支气管扩张症的121例患者。为研究目的采用以下定植定义：一年内检测到至少两种分离的微生物，且间隔至少3个月。
这121例患者中，65例（54%）为女性，56例（46%）为男性。平均年龄为50.6±16.1岁。平均病程为20.3±15.5年。43例（35.5%）病例有定植。导致定植的主要病原体为铜绿假单胞菌（n = 25；20.6%）和流感嗜血杆菌（n = 14，11.5%）。逐步逻辑回归分析显示，定植与用力肺活量百分比（FVC%）低及囊性支气管扩张的存在之间存在显著关联（P < 0.05）。
已发现以下因素与支气管扩张症患者的定植有关：低FVC%及囊性支气管扩张的存在。
