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Further proof for an unpopular concept: a single cell from bone marrow can serve as a stem cell for both hematopoiesis and osteogenesis.

作者信息

Prockop Darwin J

机构信息

Institute for Regenerative Medicine, Texas A&M Health Science Center, College of Medicine at Scott & White, Temple, Texas 76502, USA.

出版信息

Mol Ther. 2013 Jun;21(6):1116-7. doi: 10.1038/mt.2013.103.

DOI:10.1038/mt.2013.103
PMID:23728255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3677307/
Abstract
摘要

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Further proof for an unpopular concept: a single cell from bone marrow can serve as a stem cell for both hematopoiesis and osteogenesis.一个不受欢迎概念的进一步证据：来自骨髓的单个细胞可同时作为造血和骨生成的干细胞。
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Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell function.骨髓微环境中细胞成分相互作用对造血干细胞和祖细胞功能的影响。
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本文引用的文献

1
Transplanted murine long-term repopulating hematopoietic cells can differentiate to osteoblasts in the marrow stem cell niche.移植的小鼠长期重建造血细胞可在骨髓干细胞龛中分化为成骨细胞。
Mol Ther. 2013 Jun;21(6):1224-31. doi: 10.1038/mt.2013.36. Epub 2013 Apr 16.
2
The stem cell niche: tissue physiology at a single cell level.干细胞龛：单细胞水平的组织生理学。
J Clin Invest. 2012 Sep;122(9):3029-34. doi: 10.1172/JCI60238. Epub 2012 Sep 4.
3
Transplanted bone marrow mononuclear cells and MSCs impart clinical benefit to children with osteogenesis imperfecta through different mechanisms.移植的骨髓单核细胞和间充质干细胞通过不同的机制为成骨不全症患儿带来临床获益。
Blood. 2012 Aug 30;120(9):1933-41. doi: 10.1182/blood-2011-12-400085. Epub 2012 Jul 24.
4
Mesenchymal stromal cells: new directions.间质基质细胞：新方向。
Cell Stem Cell. 2012 Jun 14;10(6):709-716. doi: 10.1016/j.stem.2012.05.015.
5
Getting blood from bone: an emerging understanding of the role that osteoblasts play in regulating hematopoietic stem cells within their niche.从骨骼中获取血液：对成骨细胞在其龛位中调节造血干细胞的作用的新认识。
Exp Hematol. 2012 Sep;40(9):685-94. doi: 10.1016/j.exphem.2012.05.004. Epub 2012 May 26.
6
Medical therapies with adult stem/progenitor cells (MSCs): a backward journey from dramatic results in vivo to the cellular and molecular explanations.成体/祖细胞（MSCs）的医学治疗方法：从体内戏剧性的结果到细胞和分子解释的倒退之旅。
J Cell Biochem. 2012 May;113(5):1460-9. doi: 10.1002/jcb.24046.
7
The hematopoietic stem cell niche.造血干细胞龛。
Front Biosci (Landmark Ed). 2012 Jan 1;17(1):30-9. doi: 10.2741/3913.
8
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche.间充质和造血干细胞构成了独特的骨髓龛。
Nature. 2010 Aug 12;466(7308):829-34. doi: 10.1038/nature09262.
9
Amelioration of a mouse model of osteogenesis imperfecta with hematopoietic stem cell transplantation: microcomputed tomography studies.用造血干细胞移植改善成骨不全症小鼠模型：微计算机断层扫描研究。
Exp Hematol. 2010 Jul;38(7):593-602. doi: 10.1016/j.exphem.2010.04.008. Epub 2010 Apr 24.
10
Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms.成体干细胞/祖细胞（间充质干细胞）对组织的修复：争议、误解及不断变化的范式
Mol Ther. 2009 Jun;17(6):939-46. doi: 10.1038/mt.2009.62. Epub 2009 Mar 31.