Department of Veterinary Pharmacology and Toxicology, Shere-Kashmir University of Agricultural Sciences and Technology, Jammu, India.
Bull Environ Contam Toxicol. 2013 Jul;91(1):125-8. doi: 10.1007/s00128-013-1022-7. Epub 2013 Jun 2.
The oxidative stress-inducing potential of the pyrethroid insecticide, bifenthrin, was evaluated in rats at 5.8 mg/kg body weight once daily for 20 or 30 days. Bifenthrin treated animals showed significantly increased lipid peroxidation, evidenced by increased blood malondialdehyde levels. Blood glutathione levels and activities of catalase and glutathione peroxidase decreased significantly in the bifenthrin treated animals after both 20 and 30 days of treatment, whereas, the activities of superoxide dismutase and glutathione S-transferase decreased significantly only on the 30th day. In conclusion, bifenthrin has a potential to induce severe oxidative stress in rats exposed to sublethal concentrations.
研究人员以 5.8mg/kg 体重的剂量对大鼠进行了为期 20 天或 30 天的每日一次的吡虫啉（一种拟除虫菊酯类杀虫剂）染毒实验，以评估其诱导氧化应激的潜力。结果显示，染毒组大鼠的脂质过氧化作用显著增强，表现为血液丙二醛水平升高。在 20 天和 30 天的染毒处理后，大鼠血液中的谷胱甘肽水平以及过氧化氢酶和谷胱甘肽过氧化物酶的活性显著降低，而超氧化物歧化酶和谷胱甘肽 S-转移酶的活性仅在第 30 天显著降低。综上所述，吡虫啉在以亚致死浓度暴露的大鼠体内具有诱导严重氧化应激的潜力。
