Khan Adil Mehraj, Rampal Satyavan
Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India.
J Am Assoc Lab Anim Sci. 2014 Jul;53(4):399-403.
Prolonged antibiotic and antiinflammatory therapy for complicated infections exposes the body to xenobiotics that can produce several adverse effects for which oxidative damage is the proposed underlying mechanism. In this context, we evaluated the effect of pazufloxacin, a fluoroquinolone antimicrobial, and meloxicam, a nonsteroidal antiinflammatory drug, on antioxidant parameters and lipid peroxidation in rabbits after oral administration for 21 d. Reduced glutathione levels were significantly decreased in rabbits (n = 4 per group) given pazufloxacin, meloxicam, or their combination. In addition, glutathione peroxidase activity was induced in the rabbits treated with pazufloxacin only. Administration of pazufloxacin and meloxicam, as single agents as well as in combination, produced significant lipid peroxidation compared with levels in untreated controls. In conclusion, both pazufloxacin and meloxicam potentially can induce oxidative damage in rabbits.
针对复杂感染进行的长期抗生素和抗炎治疗会使身体接触到外源性物质，这些物质可能产生多种不良反应，氧化损伤被认为是其潜在的机制。在此背景下，我们评估了氟喹诺酮类抗菌药物甲磺酸帕珠沙星和非甾体抗炎药美洛昔康口服给药21天对家兔抗氧化参数和脂质过氧化的影响。给予甲磺酸帕珠沙星、美洛昔康或其组合的家兔（每组4只）体内还原型谷胱甘肽水平显著降低。此外，仅用甲磺酸帕珠沙星治疗的家兔体内谷胱甘肽过氧化物酶活性被诱导。与未治疗的对照组相比，单独使用或联合使用甲磺酸帕珠沙星和美洛昔康均产生了显著的脂质过氧化。总之，甲磺酸帕珠沙星和美洛昔康都有可能在家兔体内诱导氧化损伤。
