小气道疾病，不包括哮喘和 COPD：概述。
Small airways diseases, excluding asthma and COPD: an overview.
机构信息
Service de Pneumologie, Hôpital Cochin, AP-HP, Université Paris Descartes, Paris, France.
出版信息
Eur Respir Rev. 2013 Jun 1;22(128):131-47. doi: 10.1183/09059180.00001313.
This review is the summary of a workshop on small airways disease, which took place in Porquerolles, France in November 2011. The purpose of this workshop was to review the evidence on small airways (bronchiolar) involvement under various pathophysiological circumstances, excluding asthma and chronic obstructive pulmonary disease. Histopathological patterns associated with small airways disease were reviewed, including cellular and obliterative bronchiolitis. Many pathophysiological conditions have been associated with small airways disease including airway infections, connective tissue diseases and inflammatory bowel diseases, bone marrow and lung transplantation, common variable immunodeficiency disorders, diffuse panbronchiolitis, and diseases related to environmental exposures to pollutants, allergens and drugs. Pathogenesis, clinical presentation, a computed tomography scan and pulmonary function test findings are reviewed, and therapeutic options are described with the objective of providing an integrative approach to these disorders.
这篇综述是 2011 年 11 月在法国波克罗勒（Porquerolles）举行的一个关于小气道疾病研讨会的总结。本次研讨会的目的是回顾在各种病理生理情况下小气道（细支气管）受累的证据，不包括哮喘和慢性阻塞性肺疾病。我们还回顾了与小气道疾病相关的组织病理学模式，包括细胞性和闭塞性细支气管炎。许多病理生理条件与小气道疾病相关，包括气道感染、结缔组织疾病和炎症性肠病、骨髓和肺移植、常见可变免疫缺陷疾病、弥漫性泛细支气管炎，以及与环境暴露于污染物、过敏原和药物相关的疾病。本文还综述了这些疾病的发病机制、临床表现、计算机断层扫描和肺功能检查结果，并描述了治疗选择，旨在为这些疾病提供一种综合的治疗方法。
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