Virology Unit, Viral Hepatitis Laboratory, Pasteur Institute of Morocco, Casablanca, Morocco.
Clin Microbiol Infect. 2013 Oct;19(10):E454-7. doi: 10.1111/1469-0691.12252. Epub 2013 Jun 3.
Human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are major public health concerns. We aimed to determine the prevalence of HBV and HCV infections among HIV-infected patients, and to identify the main circulating hepatitis strains in Morocco. The study was carried out in 503 HIV-infected patients. Our survey indicated that the prevalence of HIV/hepatitis co-infection was 10.6%; 5.2% of patients were HBV surface antigen positive, and 5.4% of patients were anti-HCV positive. Among the HBV surface antigen-positive group, HBV DNA sequencing identified exclusively genotype D (D1: 26.7%; D7: 73.3%) in accordance with what is found in the general population. In contrast, sequencing of HCV isolates produced an unusual subtype distribution with a decreasing order of prevalence: 1a, 3a (both 23.5%), 1b, 4a (both 17.6%), 1c (11.8%) and 6h (6%).
人类免疫缺陷病毒（HIV）、乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）是主要的公共卫生关注点。我们旨在确定 HIV 感染患者中 HBV 和 HCV 感染的流行率，并确定摩洛哥的主要流行肝炎毒株。该研究在 503 名 HIV 感染患者中进行。我们的调查表明，HIV/肝炎合并感染的患病率为 10.6%；5.2%的患者 HBV 表面抗原阳性，5.4%的患者抗-HCV 阳性。在 HBV 表面抗原阳性组中，HBV DNA 测序仅确定基因型 D（D1：26.7%；D7：73.3%），与一般人群中的发现一致。相比之下，HCV 分离株的测序产生了一种不寻常的亚型分布，其流行率依次递减：1a、3a（均为 23.5%）、1b、4a（均为 17.6%）、1c（11.8%）和 6h（6%）。
