Berens S, Vogt P, Alkadhi H, Berger N, Moch H
Institut für Klinische Pathologie, UniversitätsSpital Zürich, Zürich, Schweiz,
Pathologe. 2014 Feb;35(1):83-7. doi: 10.1007/s00292-013-1772-3.
Thyroid-like follicular carcinoma of the kidney is postulated as a potentially new entity of renal tumor based on nine previously published case reports. This tumor entity is not yet integrated into the classification of tumors of the World Health Organization (WHO). In this article a new case of thyroid-like follicular carcinoma of kidney is described which was incidentally detected at autopsy. The 58-year-old patient died of complications of acute myeloid leukemia after chemotherapy and also had prostatic adenocarcinoma. The renal tumor in the left kidney had a diameter of 3 cm and showed a grey-brown cut surface. Histologically, the tumor presented with a typical thyroid-like microfollicular and macrofollicular structure filled with eosinophilic, colloid-like material with calcification. Immunohistologically the renal tumor was CD 10 positive and negative for thyroid transcription factor 1 (TTF1) and thyroglobulin. A synopsis of the published case reports indicates that thyroid-like follicular carcinoma of the kidney has a low risk of metastasis. More experience with further cases of thyroid-like follicular renal carcinoma is necessary before a recommendation of a separate tumor entity in the next WHO classification is justified.
基于之前发表的9例病例报告,肾甲状腺样滤泡癌被假定为一种潜在的新型肾肿瘤实体。该肿瘤实体尚未纳入世界卫生组织(WHO)的肿瘤分类中。本文描述了1例在尸检时偶然发现的肾甲状腺样滤泡癌新病例。该58岁患者在化疗后死于急性髓系白血病并发症,同时还患有前列腺腺癌。左肾的肾肿瘤直径为3 cm,切面呈灰棕色。组织学上,肿瘤呈现典型的甲状腺样微滤泡和大滤泡结构,充满嗜酸性、胶体样物质并伴有钙化。免疫组织化学检查显示,该肾肿瘤CD 10阳性,甲状腺转录因子1(TTF1)和甲状腺球蛋白阴性。已发表病例报告的综述表明,肾甲状腺样滤泡癌转移风险较低。在WHO下一次分类中推荐将其作为一个单独的肿瘤实体之前,需要积累更多肾甲状腺样滤泡癌病例的经验。