Muscara Matthew J, Simper Novae B, Gandia Edwin
1 Madigan Army Medical Center, Tacoma, WA, USA.
2 Womack Army Medical Center, Fort Bragg, NC, USA.
Int J Surg Pathol. 2017 Feb;25(1):73-77. doi: 10.1177/1066896916662153. Epub 2016 Jul 29.
Thyroid-like follicular carcinoma of the kidney (TLFCK) is a rare but emerging renal neoplasm that morphologically mimics follicular carcinoma of the thyroid but lacks immunohistochemical expression of thyroid markers such as TTF-1 and thyroglobulin. Here, a case of an incidentally discovered TLFCK in a 27-year-old man is reported. Histologic evaluation demonstrated an encapsulated proliferation of variably sized thyroid follicle-like epithelial-lined spaces filled with colloid-like eosinophilic secretions. Immunohistochemical analysis confirmed lack of expression of the thyroid markers TTF-1 and thyroglobulin with expression of PAX8 and CD10, confirming a neoplasm of renal origin, which correlated to the clinical and radiographic absence of thyroid pathology. In this report, this case is described with an emphasis on the differential diagnosis.
肾甲状腺样滤泡癌（TLFCK）是一种罕见但正在被认识的肾脏肿瘤，其形态学上类似于甲状腺滤泡癌，但缺乏甲状腺标志物如TTF-1和甲状腺球蛋白的免疫组化表达。在此，报告一例27岁男性偶然发现的TLFCK病例。组织学评估显示有大小不一的甲状腺滤泡样上皮内衬间隙的包膜内增殖，间隙内充满胶样嗜酸性分泌物。免疫组化分析证实缺乏甲状腺标志物TTF-1和甲状腺球蛋白的表达，而PAX8和CD10表达阳性，证实为肾脏起源的肿瘤，这与临床和影像学检查未发现甲状腺病变相符。在本报告中，描述了该病例并重点强调了鉴别诊断。
