Univ Paris Diderot, Sorbonne Paris Cité; Institut des Energies de Demain (IED, FRE 3597); Paris, France; Institut de Biologie des Plantes; Orsay, France.
Plant Signal Behav. 2013 Aug;8(8). doi: 10.4161/psb.25170. Epub 2013 Jun 3.
Using A. thaliana cultured cells; we recently reported new insights regarding the effect of acute O₃ exposure. This consist in an oxidative dependent controlled cell death process involving cell shrinkage due to an early activation of anion channel (1) and a delayed activation of K(+) outward currents, but also to early events like Ca (2+) influx or singlet oxygen production possibly linked to mitochondrial dysfunction. Here we provide evidence that most of these early events act downstream of caspase-like activities as recently demonstrated for K(+) channel activation.
我们最近使用拟南芥培养细胞报告了有关急性 O₃暴露影响的新见解。这涉及到一种依赖氧化的受控细胞死亡过程，该过程因阴离子通道的早期激活（1）和 K(+)外向电流的延迟激活而导致细胞收缩，但也涉及到 Ca(2+)内流或可能与线粒体功能障碍有关的单线态氧产生等早期事件。正如最近对 K(+)通道激活所证明的那样，这里我们提供的证据表明，这些早期事件中的大多数都作用于半胱天冬酶样活性的下游。
