National Resource Center for Rehabilitation in Rheumatology, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Eur J Pain. 2014 Jan;18(1):120-7. doi: 10.1002/j.1532-2149.2013.00338.x. Epub 2013 Jun 3.
Multisite pain and obesity are cross-sectionally related and are common conditions that may influence each other through socio-demographic, lifestyle and/or health-related factors. The aim of the present study was to examine the cross-sectional and prospective associations between overweight/obesity and multisite pain in a general population.
In a 20-year population-based prospective cohort study, persons aged 20-62 years in 1990 participated in postal surveys in 1990, 1994, 2004 and 2010 (n = 855). Multisite pain was defined as reporting ≥ 2 number of pain sites (NPS) on the Standardized Nordic Questionnaire. Overweight was defined as body mass index (BMI) 25-30 kg/m(2) and obesity as BMI ≥ 30 kg/m(2). To exploit all measurement times, generalized estimating equation analyses adjusting for age, sex, educational and occupational status, smoking, sleep quality, mental distress and physical activity were employed.
The mean age was 41 years at baseline and 57% were women. Overweight/obesity and NPS were significantly associated cross-sectionally. Being overweight/obese was associated with reporting future NPS ≥ 2 [overweight: odds ratio (OR), 1.40, 95% confidence interval (CI), 1.12-1.75, obese: OR, 1.54, 95% CI, 1.04-2.28]. Having NPS ≥ 2 was not associated with becoming overweight, but increased the OR for future obesity (OR 1.27, 95% CI, 1.02, 1.59). Smoking was a confounder in this relationship.
Being overweight or obese was associated with future multisite pain, although the magnitude of the association was small and the dose-response relationship observed in cross-sectional analyses disappeared in prospective analyses. There was less evidence that having multisite pain was a predictor of future overweight/obesity.
多部位疼痛和肥胖呈横断面相关，且为常见病症，可能通过社会人口学、生活方式和/或健康相关因素相互影响。本研究旨在调查一般人群中超重/肥胖与多部位疼痛的横断面和前瞻性关联。
在一项为期 20 年的基于人群的前瞻性队列研究中，1990 年年龄在 20-62 岁的人群参加了 1990 年、1994 年、2004 年和 2010 年的邮政调查（n=855）。多部位疼痛的定义是报告标准北欧问卷上≥2 个疼痛部位（NPS）。超重定义为体重指数（BMI）25-30kg/m2，肥胖定义为 BMI≥30kg/m2。为了充分利用所有测量时间，采用广义估计方程分析，根据年龄、性别、教育和职业状况、吸烟、睡眠质量、精神困扰和体力活动进行调整。
基线时平均年龄为 41 岁，57%为女性。超重/肥胖与 NPS 呈显著横断面相关。超重/肥胖与报告未来 NPS≥2 相关[超重：比值比（OR）1.40，95%置信区间（CI）1.12-1.75，肥胖：OR 1.54，95%CI 1.04-2.28]。有 NPS≥2 与超重无关，但增加了未来肥胖的 OR（OR 1.27，95%CI 1.02-1.59）。吸烟是该关系的混杂因素。
超重或肥胖与未来多部位疼痛相关，尽管关联幅度较小，且横断面分析中观察到的剂量-反应关系在前瞻性分析中消失。多部位疼痛作为未来超重/肥胖的预测因素的证据较少。
