p21 小分子抑制剂作为化疗耐药肾细胞癌的新型治疗药物。
Small-molecule inhibitors of p21 as novel therapeutics for chemotherapy-resistant kidney cancer.
机构信息
Department of Biochemistry & Molecular Medicine, University of California Davis, Sacramento, CA 95817, USA.
出版信息
Future Med Chem. 2013 Jun;5(9):991-4. doi: 10.4155/fmc.13.56.
Abstract
“In the search for novel approaches for the treatment of resistant cancers, small molecules targeting the cyclin dependent kinase inhibitors have shown considerable promise”
摘要
在寻找治疗耐药性癌症的新方法的过程中，靶向细胞周期蛋白依赖性激酶抑制剂的小分子显示出了相当大的前景。
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2
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3
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