Instituto Nacional de Salud Pública (INSP), Avenida Universidad, Colonia Santa María Ahuacatitlán, Cuernavaca, Morelos, México.
GlaxoSmithKline Vaccines, Avenue Fleming 20 (W23), Wavre, Belgium.
Epidemiol Infect. 2014 Apr;142(4):706-13. doi: 10.1017/S0950268813001313. Epub 2013 Jun 5.
SUMMARY Serum samples collected during the National Health and Nutrition survey (ENSANUT 2006) were obtained from subjects aged 1-95 years (January-October 2010) and analysed to assess the seroprevalence of Bordetella pertussis (BP) in Mexico. Subjects' gender, age, geographical region and socioeconomic status were extracted from the survey and compiled into a subset database. A total of 3344 subjects (median age 29 years, range 1-95 years) were included in the analysis. Overall, BP seroprevalence was 47.4%. BP seroprevalence was significantly higher in males (53.4%, P = 0.0007) and highest in children (59.3%) decreasing with advancing age (P = 0.0008). BP seroprevalence was not significantly different between regions (P = 0.1918) and between subjects of socioeconomic status (P = 0.0808). Women, adolescents and young adults were identified as potential sources of infection to infants. Booster vaccination for adolescents and primary contacts (including mothers) for newborns and infants may provide an important public health intervention to reduce the disease burden.
血清样本采集于 2006 年全国健康和营养调查（ENSANUT 2006）期间，来自年龄在 1-95 岁的调查对象（2010 年 1 月至 10 月），并进行分析以评估博德特氏菌（BP）在墨西哥的血清流行率。调查中提取了调查对象的性别、年龄、地理位置和社会经济地位，并将其编制成一个子集数据库。共纳入 3344 名调查对象（中位数年龄 29 岁，范围 1-95 岁）进行分析。总体而言，BP 的血清流行率为 47.4%。男性的 BP 血清流行率（53.4%）明显高于女性（P = 0.0007），且儿童的流行率最高（59.3%），随年龄增长而下降（P = 0.0008）。地区之间（P = 0.1918）和社会经济地位之间（P = 0.0808）的 BP 血清流行率无显著差异。女性、青少年和年轻成年人是婴儿感染的潜在来源。对青少年和新生儿及婴儿的主要接触者（包括母亲）进行加强疫苗接种可能为减少疾病负担提供重要的公共卫生干预措施。
