Chen Zhiyun, He Qiushui
a Department of Medical Microbiology and Research Centre of Microbiome , Capital Medical University , Beijing , China.
b Department of Medical Microbiology and Immunology , University of Turku , Turku , Finland.
Hum Vaccin Immunother. 2017 Apr 3;13(4):744-756. doi: 10.1080/21645515.2016.1259780. Epub 2017 Jan 3.
Pertussis is one of the most prevalent vaccine-preventable diseases worldwide. The true infection rate is significantly higher than the reported incidence rate. An increased prevalence of pertussis in older populations has been found, mainly caused by waning immunity after vaccination. Vaccine-induced immunity differs due to variation in vaccine content, schedule and coverage. Protection following acellular pertussis vaccines has been suggested to wane faster than whole cell pertussis vaccines. However, long-term immune persistence of whole cell pertussis vaccines may be confounded by a progressive acquisition of natural immunity. The World Health Organization has recommended that a switch from whole cell to acellular pertussis vaccines for primary immunization in infants should only be considered if additional periodic boosters or maternal immunization can be ensured and sustained in the national immunization schedules. In this review, we present data on immune persistence after different pertussis vaccinations and compare the findings from countries with different vaccination strategies. Future aspects in serological studies are briefly discussed.
百日咳是全球最常见的可通过疫苗预防的疾病之一。实际感染率显著高于报告发病率。已发现老年人群中百日咳患病率增加，主要原因是疫苗接种后免疫力下降。由于疫苗成分、接种程序和覆盖率的差异，疫苗诱导的免疫力也有所不同。有人认为，无细胞百日咳疫苗诱导的保护作用比全细胞百日咳疫苗消退得更快。然而，全细胞百日咳疫苗的长期免疫持久性可能会因自然免疫力的逐步获得而受到混淆。世界卫生组织建议，只有在国家免疫规划中能够确保并持续进行额外的定期加强免疫或母体免疫时，才应考虑在婴儿的初次免疫中从全细胞百日咳疫苗转向无细胞百日咳疫苗。在本综述中，我们展示了不同百日咳疫苗接种后的免疫持久性数据，并比较了采用不同疫苗接种策略的国家的研究结果。还简要讨论了血清学研究的未来方向。
