Sullivan Nicholas, Elzinga Sytze, Raber Jeffrey C
The Werc Shop, Inc., Pasadena, CA 91107, USA.
J Toxicol. 2013;2013:378168. doi: 10.1155/2013/378168. Epub 2013 May 12.
The present study was conducted in order to quantify to what extent cannabis consumers may be exposed to pesticide and other chemical residues through inhaled mainstream cannabis smoke. Three different smoking devices were evaluated in order to provide a generalized data set representative of pesticide exposures possible for medical cannabis users. Three different pesticides, bifenthrin, diazinon, and permethrin, along with the plant growth regulator paclobutrazol, which are readily available to cultivators in commercial products, were investigated in the experiment. Smoke generated from the smoking devices was condensed in tandem chilled gas traps and analyzed with gas chromatography-mass spectrometry (GC-MS). Recoveries of residues were as high as 69.5% depending on the device used and the component investigated, suggesting that the potential of pesticide and chemical residue exposures to cannabis users is substantial and may pose a significant toxicological threat in the absence of adequate regulatory frameworks.
本研究旨在量化大麻消费者通过吸入主流大麻烟雾可能接触农药和其他化学残留物的程度。评估了三种不同的吸烟装置，以提供一组具有代表性的通用数据，反映医用大麻使用者可能接触农药的情况。实验中研究了三种不同的农药，联苯菊酯、二嗪农和氯菊酯，以及种植者在商业产品中容易获得的植物生长调节剂多效唑。吸烟装置产生的烟雾在串联的冷却气体阱中冷凝，并用气相色谱-质谱联用仪（GC-MS）进行分析。根据所使用的装置和所研究的成分，残留物的回收率高达69.5%，这表明大麻使用者接触农药和化学残留物的可能性很大，在缺乏适当监管框架的情况下，可能构成重大的毒理学威胁。
