Nambiar P R, Jackson M L, Ellis J A, Chelack B J, Kidney B A, Haines D M
Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.
Vet Pathol. 2001 Mar;38(2):236-8. doi: 10.1354/vp.38-2-236.
Sarcomas associated with injection sites are a rare but important problem in cats. Immunohistochemical detection of p53 protein may correlate to mutation of the p53 tumor suppressor gene, a gene known to be important in oncogenesis. The expression of nuclear p53 protein in 40 feline injection site-assocated sarcomas was examined by immunohistochemical staining. In 42.5% (17/40), tumor cell nuclei were stained darkly; in 20% (8/40), tumor cell nuclei were stained palely; and in 37.5% (15/40), tumor cell nuclei were unstained. Immunohistochemical detection of p53 protein in a proportion of injection site-associated sarcomas suggests that mutation of the p53 gene may play a role in the pathogenesis of these tumors.
与注射部位相关的肉瘤在猫中是一个罕见但重要的问题。p53蛋白的免疫组织化学检测可能与p53肿瘤抑制基因的突变相关，该基因在肿瘤发生中起重要作用。通过免疫组织化学染色检测了40例猫注射部位相关肉瘤中核p53蛋白的表达。42.5%（17/40）的肿瘤细胞核染色深；20%（8/40）的肿瘤细胞核染色浅；37.5%（15/40）的肿瘤细胞核未染色。在一部分注射部位相关肉瘤中p53蛋白的免疫组织化学检测表明，p53基因的突变可能在这些肿瘤的发病机制中起作用。
