Nurulain Syed M, Szegi Peter, Tekes Kornèlia, Naqvi Syed N H
Department of Pharmacology and Therapeutic, Faculty of Medicine and Health Sciences, UAE University, AlAin UAE.
Arh Hig Rada Toksikol. 2013;64(1):169-77. doi: 10.2478/10004-1254-64-2013-2294.
Oxidative stress has recently been implicated as a factor in the mortality and morbidity induced by organophosphorus (OP) compound poisoning. An overwhelming number of research papers are based on studying at the cellular and organ level. Such studies have concluded that antioxidants can be used as an adjunct compound in the treatment of both chronic as well as acute OP poisoning. Still, the role of antioxidants in reducing the mortality and morbidity induced by OP compounds has scarcely been verified, as well as their role as adjunct treatment compounds for both structurally and functionally different OP compounds. The present review of the literature was undertaken to establish the role of antioxidants in survival studies following acute exposure to OP compounds. The review found no substantial evidence that antioxidants demonstrate any positive effect following extremely toxic poisoning. However, for a more comprehensive and rational conclusion, further research needs to be conducted.
氧化应激最近被认为是有机磷（OP）化合物中毒所致死亡率和发病率的一个因素。绝大多数研究论文都是基于细胞和器官水平的研究。此类研究得出结论，抗氧化剂可作为辅助化合物用于治疗慢性和急性OP中毒。然而，抗氧化剂在降低OP化合物所致死亡率和发病率方面的作用几乎未得到证实，其作为结构和功能不同的OP化合物辅助治疗化合物的作用也未得到证实。本综述旨在确定抗氧化剂在急性接触OP化合物后的生存研究中的作用。该综述未发现实质性证据表明抗氧化剂在剧毒中毒后有任何积极作用。然而，为了得出更全面和合理的结论，还需要进一步开展研究。
