Division of Genomics and Computational Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Bioinformatics. 2013 Aug 1;29(15):1895-7. doi: 10.1093/bioinformatics/btt315. Epub 2013 Jun 5.
At the heart of many modern biotechnological and therapeutic applications lies the need to target specific genomic loci with pinpoint accuracy. Although landmark experiments demonstrate technological maturity in manufacturing and delivering genetic material, the genomic sequence analysis to find suitable targets lags behind. We provide a computational aid for the sophisticated design of sequence-specific ligands and selection of appropriate targets, taking gene location and genomic architecture into account.
Source code and binaries are downloadable from www.bioinformatics.org.au/triplexator/inspector.
Supplementary data are available at Bioinformatics online.
在许多现代生物技术和治疗应用的核心，需要以极高的精度靶向特定的基因组位点。虽然具有里程碑意义的实验证明了制造和递送遗传物质的技术成熟度，但寻找合适目标的基因组序列分析却落后了。我们提供了一种计算辅助工具，用于在考虑基因位置和基因组结构的情况下，对序列特异性配体进行复杂设计和合适靶标的选择。
可从 www.bioinformatics.org.au/triplexator/inspector 下载源代码和二进制文件。
补充数据可在Bioinformatics 在线获得。
