多氯联苯暴露人群中的基因状况：简要概述。
Status of Gene in PCB-exposed Population: A Quick Look.
作者信息
Ghosh Somiranjan, Trnovec Tomas, Palkovicova Lubica, Hoffman Eric P, Washington Kareem, Dutta Sisir K
机构信息
Department of Biology, Howard University, Washington DC, USA.
出版信息
Int J Hum Genet. 2013 Mar;13(1):27-32. doi: 10.1080/09723757.2013.11886193.
Abstract
Earlier, we have reported that Polychlorinated Biphenyls (PCBs) exposure in Slovak population has made differential gene expression that has linked to the possibilities of some diseases and disorder development in the studied population. Here we report that down-regulation of LEPR (Leptin receptor) gene in the 45-month children may have been following consequences in developing obesity later in life. A pilot high-throughput qRT-PCR [Taqman Low Density Array (TLDA)] study in a small population also corroborated the gene-expression results, and their pathways underlying the consequences of the diseases, amid further detailed large-scale population validation. The study shows the opportunity of predicting long-term effects of chemical exposures using selected genomic classifiers may reflect exposure effect and risk from environmental toxicants.
摘要
此前，我们曾报道斯洛伐克人群接触多氯联苯（PCBs）会导致基因表达差异，这与研究人群中某些疾病和紊乱的发生可能性有关。在此我们报告，45个月大儿童中瘦素受体（LEPR）基因的下调可能会在其日后的生活中导致肥胖。在一小部分人群中进行的一项高通量qRT-PCR[Taqman低密度阵列（TLDA）]初步研究也证实了基因表达结果及其在疾病后果中的潜在途径，同时还需进一步进行大规模人群验证。该研究表明，利用选定的基因组分类器预测化学物质暴露的长期影响，可能反映环境毒物的暴露效应和风险。
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