Institute for Regenerative Medicine and Biomimetic Materials, State Key Laboratory of New Ceramics and Fine Processing, Department of Materials Science and Engineering , Tsinghua University , Beijing 100084 , People's Republic of China.
Interface Focus. 2012 Jun 6;2(3):278-91. doi: 10.1098/rsfs.2012.0016. Epub 2012 Mar 21.
Central nervous system (CNS) regeneration with central neuronal connections and restoration of synaptic connections has been a long-standing worldwide problem and, to date, no effective clinical therapies are widely accepted for CNS injuries. The limited regenerative capacity of the CNS results from the growth-inhibitory environment that impedes the regrowth of axons. Central neural tissue engineering has attracted extensive attention from multi-disciplinary scientists in recent years, and many studies have been carried out to develop cell- and regeneration-activating biomaterial scaffolds that create an artificial micro-environment suitable for axonal regeneration. Among all the biomaterials, hyaluronic acid (HA) is a promising candidate for central neural tissue engineering because of its unique physico-chemical and biological properties. This review attempts to outline current biomaterials-based strategies for CNS regeneration from a tissue engineering point of view and discusses the main progresses in research of HA-based scaffolds for central neural tissue engineering in detail.
中枢神经系统（CNS）的再生与中枢神经元连接的恢复和突触连接的恢复一直是一个全球性的长期问题，迄今为止，对于 CNS 损伤还没有被广泛接受的有效临床治疗方法。CNS 的再生能力有限，这是由于生长抑制性环境阻碍了轴突的再生。近年来，中枢神经组织工程引起了多学科科学家的广泛关注，许多研究已经开展，以开发细胞和再生激活的生物材料支架，为轴突再生创造合适的人工微环境。在所有的生物材料中，透明质酸（HA）因其独特的物理化学和生物学特性而成为中枢神经组织工程的有前途的候选材料。本综述试图从组织工程的角度概述当前基于生物材料的 CNS 再生策略，并详细讨论基于 HA 的支架在中枢神经组织工程研究中的主要进展。
