School of Nursing, University of Cadiz, 11003 Cadiz, Spain.
School of Medicine, University of Cadiz, 11003 Cadiz, Spain.
Int J Environ Res Public Health. 2021 Aug 26;18(17):8996. doi: 10.3390/ijerph18178996.
Recent studies have emphasized that regular exercise should be encouraged as a key part of care and support for people with Down syndrome (DS). However, muscle hypotonia has traditionally been considered a major barrier to resistance training (RT) in people with DS. The main objective of this study was to analyze the impact of circuit RT on markers of muscle damage. The secondary objective was to assess the influence of a RT program on body composition and work task performance. Thirty-six men with DS were recruited and randomly assigned to perform a circuit RT program with six stations 3 days/week for 12 weeks (n = 18) or to a control group (n = 18). Body composition was assessed by bioelectrical impedance analysis. Serum markers of muscle damage (creatine kinase, myoglobin, and lactate dehydrogenase) were determined at baseline and at the end of training weeks 1, 6, and 12. Work task performance was assessed using the weighted pail-carry test. RT did not induce significant changes in markers of muscle damage during the intervention. Furthermore, muscle mass and work task performance were significantly improved in the exercise group. These findings suggest that circuit RT can be used safely to increase muscle mass and work task performance in young adults with DS. Muscle hypotonia should not be considered a major barrier to exercise in people with DS, provided that qualified staff design and supervise all training sessions.
最近的研究强调，应鼓励经常锻炼，将其作为唐氏综合征（DS）患者护理和支持的关键部分。然而，肌肉张力减退一直被认为是 DS 患者进行抗阻训练（RT）的主要障碍。本研究的主要目的是分析循环 RT 对肌肉损伤标志物的影响。次要目的是评估 RT 方案对身体成分和工作任务表现的影响。招募了 36 名男性 DS 患者，并将他们随机分配到 3 天/周进行 6 站循环 RT 方案组（n = 18）或对照组（n = 18）。使用生物电阻抗分析评估身体成分。在基线和训练第 1、6 和 12 周结束时，测定血清肌肉损伤标志物（肌酸激酶、肌红蛋白和乳酸脱氢酶）。使用加权桶搬运测试评估工作任务表现。RT 干预期间，肌肉损伤标志物没有显著变化。此外，运动组的肌肉质量和工作任务表现显著提高。这些发现表明，循环 RT 可以安全地用于增加年轻 DS 患者的肌肉质量和工作任务表现。只要有合格的工作人员设计和监督所有的训练课程，肌肉张力减退不应被视为 DS 患者运动的主要障碍。
