Department of Paediatrics, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.
Phytother Res. 2014 Mar;28(3):471-4. doi: 10.1002/ptr.5020. Epub 2013 Jun 7.
Recurrent respiratory tract infections (RRTIs) present a very important problem in paediatric praxis. As true immunodeficiencies are rare, one of the most important factors assumed to contribute to increased respiratory morbidity is atopy. Several preparations of natural origin have been used for the prevention of RRTIs, and some of the most effective immunomodulators are biologically active polysaccharides - e.g. ß-glucans. In our randomised, double-blind, placebo-controlled study, we investigated the prevalence of atopy in a group of children with RRTIs and the potential anti-allergic effect of pleuran (ß-glucan isolated from Pleurotus ostreatus) on basic laboratory markers of allergic inflammation. We confirmed that atopy may be an important factor contributing to the increased respiratory morbidity in children with RRTIs. The active treatment with pleuran resulted in a significant reduction of peripheral blood eosinophilia and stabilised the levels of total IgE in serum. This was more evident in atopic subjects. Pleuran showed a potential anti-allergic effect. This previously non-described effect could expand the application of this natural immunomodulator also as a complementary adjuvant therapy in allergic patients.
反复呼吸道感染（RRTIs）在儿科实践中是一个非常重要的问题。由于真正的免疫缺陷很少见，被认为导致呼吸道发病率增加的一个重要因素是特应性。已经使用了几种天然来源的制剂来预防 RRTIs，一些最有效的免疫调节剂是生物活性多糖 - 例如 β-葡聚糖。在我们的随机、双盲、安慰剂对照研究中，我们调查了一组 RRTIs 患儿的特应性患病率，以及 pleuran（从平菇中分离出的 β-葡聚糖）对过敏性炎症的基本实验室标志物的潜在抗过敏作用。我们证实特应性可能是导致 RRTIs 患儿呼吸道发病率增加的一个重要因素。 pleuran 的积极治疗导致外周血嗜酸性粒细胞增多显著减少，并稳定血清总 IgE 水平。在特应性患者中更为明显。 pleuran 显示出潜在的抗过敏作用。这种以前未描述的作用可能会扩大这种天然免疫调节剂的应用范围，也可以作为过敏患者的辅助治疗。
