Clinical Laboratory of Institute for Respiratory Disease, 5983 Nova Polianka-High Tatras, Slovakia.
Appl Physiol Nutr Metab. 2010 Dec;35(6):755-62. doi: 10.1139/H10-070.
Excessive and exhausting physical loads depress the immune system. Carbohydrate consumption may minimize the postexercise suppression of the innate immune system. β-Glucan is a well-known immunomodulator, with positive effects on the functioning of immunocompetent cells. The goal of this study was to determine whether β-glucan dietary supplementation from the mushroom Pleurotus ostreatus decreases the suppressed immune system responses induced by short-term high-intensity exercise in humans. In this double-blind pilot study, 20 elite athletes were randomized to β-glucan (n = 9) or placebo (n = 11) groups; these groups consumed 100 mg of β-glucan (Imunoglukan) or placebo supplements, respectively, once a day for 2 months. Venous whole blood was collected before and after 2 months of supplementation (baseline), both immediately and 1 h after (recovery period) a 20-min intensive exercise bout at the end of the supplementation period. The blood samples were used to measure the cell counts of leukocytes, erythrocyte, and lymphocytes; subpopulations of lymphocytes, granulocytes, and monocytes; and natural killer (NK) cell activity (NKCA). A 28% reduction in NKCA (p < 0.01) below the baseline value was observed in the placebo group during the recovery period, whereas no significant reduction in NKCA was found in the β-glucan group. In addition, no significant decrease in NK cell count was measured in the β-glucan group during the recovery period. Immune cell counts did not differ significantly between the groups. These results indicate that insoluble β-glucan supplementation from P. ostreatus may play a role in modulating exercise-induced changes in NKCA in intensively training athletes.
过度和疲劳的体力负荷会抑制免疫系统。碳水化合物的消耗可能会最大限度地减少运动后先天免疫系统的抑制。β-葡聚糖是一种众所周知的免疫调节剂，对免疫细胞的功能有积极影响。本研究的目的是确定来自平菇的β-葡聚糖膳食补充剂是否会降低短期高强度运动对人体免疫系统的抑制反应。在这项双盲先导研究中，将 20 名精英运动员随机分为β-葡聚糖（n=9）或安慰剂（n=11）组；这些组分别每天服用 100mg 的β-葡聚糖（Imunoglukan）或安慰剂补充剂，持续 2 个月。在补充 2 个月（基线）前后、补充结束后 20 分钟剧烈运动后立即和 1 小时后（恢复期）采集静脉全血。使用血液样本测量白细胞、红细胞和淋巴细胞的细胞计数；淋巴细胞、粒细胞和单核细胞的亚群；以及自然杀伤（NK）细胞活性（NKCA）。在安慰剂组中，NKCA 在恢复期下降了 28%（p<0.01），低于基线值，而在β-葡聚糖组中未发现 NKCA 显著下降。此外，在恢复期β-葡聚糖组中 NK 细胞计数没有显著下降。两组之间的免疫细胞计数没有显著差异。这些结果表明，来自平菇的不溶性β-葡聚糖补充可能在调节训练有素的运动员运动引起的 NKCA 变化方面发挥作用。
