Nosál'ová V, Bobek P, Cerná S, Galbavý S, Stvrtina S
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava.
Physiol Res. 2001;50(6):575-81.
The effects of pleuran, beta-1,3 glucan isolated from Pleurotus ostreatus, were studied in a model of acute colitis induced by intracolonic administration of acetic acid. There was a reduction of the colonic damage score, colonic wet weight and wet/dry weight ratio 48 h after single luminal 2% pleuran suspension pretreatment. Similar results were obtained after repeated intraperitoneal administration of pleuran in doses of 30 and 100 mg/kg. Pleuran given orally as a 10% food component over 4 weeks was effective in reducing the extent of mucosal damage, but did not prevent the increase of myeloperoxidase in the injured colonic segment. In the segment without macroscopic evidence of inflammation, myeloperoxidase activity was significantly lower as documented by histological examination. The results indicate a possible role of this immunomodulator in the treatment of ulcerative colitis.
研究了从平菇中分离出的β-1,3-葡聚糖（即云芝多糖）在通过结肠内注射醋酸诱导的急性结肠炎模型中的作用。在单次管腔内给予2%云芝多糖悬浮液预处理48小时后，结肠损伤评分、结肠湿重和湿/干重比均有所降低。在以30和100mg/kg的剂量反复腹腔注射云芝多糖后，也获得了类似的结果。在4周内将云芝多糖作为10%的食物成分口服，可有效减轻黏膜损伤程度，但不能阻止受损结肠段中髓过氧化物酶的增加。在没有宏观炎症证据的结肠段中，组织学检查显示髓过氧化物酶活性显著降低。结果表明这种免疫调节剂在溃疡性结肠炎治疗中可能发挥作用。
