通过主客体包合作用实现 pH 开关的宏观组装。
pH-Switchable macroscopic assembly through host-guest inclusion.
机构信息
State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Chengdu 610065, China.
出版信息
Macromol Rapid Commun. 2013 Jul 25;34(14):1174-80. doi: 10.1002/marc.201300289. Epub 2013 Jun 7.
A novel pH-switchable macroscopic assembly is reported using alginate-based hydrogels functionalized with host (α-cyclodextrin, αCD) and guest (diethylenetriamine, DETA) moieties. Since the interaction of αCD and DETA is pH sensitive, the host hydrogel and guest hydrogel could adhere together when the pH is 11.5 and separate when the pH is 7.0. Furthermore, this pH-controlled adhesion and dissociation shows a good reversibility. The host and guest polymers have good biocompatibility; therefore, this pH-sensitive macroscopic assembly shows great potential in biotechnological and biomedical applications.
本文报道了一种新型 pH 响应性宏观组装体，该组装体使用了带有主体（α-环糊精，αCD）和客体（二亚乙基三胺，DETA）部分的基于藻酸盐的水凝胶。由于αCD 和 DETA 的相互作用对 pH 敏感，因此当 pH 为 11.5 时，主体水凝胶和客体水凝胶可以黏附在一起，而当 pH 为 7.0 时它们又可以分离。此外，这种 pH 控制的黏附和解离具有良好的可逆性。主体和客体聚合物具有良好的生物相容性；因此，这种 pH 敏感性宏观组装体在生物技术和生物医学应用中具有巨大的潜力。
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