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基于环糊精超分子自组装的HO响应性纳米颗粒

HO-Responsive Nanoparticle Based on the Supramolecular Self-Assemble of Cyclodextrin.

作者信息

Dong Zhenqiang, Kang Yang, Yuan Qijuan, Luo Manli, Gu Zhipeng

机构信息

Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Engineering, Sun Yat-sen University, Guangzhou, China.

College of Chemical and Material Engineering, Quzhou University, Quzhou, China.

出版信息

Front Pharmacol. 2018 May 28;9:552. doi: 10.3389/fphar.2018.00552. eCollection 2018.

DOI:10.3389/fphar.2018.00552
PMID:29892222
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5985298/
Abstract

Designing stimuli responsive, controllable and biocompatible multifunctional nanoparticles is an important progress in the current quest for drug delivery systems. Herein, we devoted to developing a β-cyclodextrin (β-CD) based drug delivery nanoparticles (NPs) that release Bovine serum albumin (BSA) via glucose-responsive gate. The design involves synthesis of sodium alginate with β-CD modified (Alg-β-CD) and methoxypolyethylene glycol (mPEG-Fc) containing ferrocene (Fc) uncharged end-capping. When α-cyclodextrin (α-CD) was added with these two segments, the stable non-covalent supramolecular structure of Alg-β-CD/mPEG-Fc/α-CD can be self-assembled into NPs in aqueous solution. BSA loaded Alg-β-CD/mPEG-Fc/α-CD also has been prepared. Interestingly, these supramolecular Alg-β-CD/mPEG-Fc/α-CD/BSA NPs showed uniform sphere structure and constant BSA loading content. Also, this new kind of NPs can disassemble in the present of hydrogen peroxide (HO). Since glucose oxidase (GOD) can oxidize glucose and produce HO, so this kind of polymeric NPs can also have glucose responsive behavior in the GOD containing environment. Developed functional Alg-β-CD/mPEG-Fc/α-CD might be a promising drug delivery strategy for diabetes or immunotherapy with more efficiency.

摘要

设计具有刺激响应性、可控性和生物相容性的多功能纳米粒子是当前药物递送系统研究中的一项重要进展。在此，我们致力于开发一种基于β-环糊精（β-CD）的药物递送纳米粒子（NPs），其通过葡萄糖响应门控释放牛血清白蛋白（BSA）。该设计涉及合成用β-CD修饰的海藻酸钠（Alg-β-CD）和含有二茂铁（Fc）无电荷封端的甲氧基聚乙二醇（mPEG-Fc）。当将α-环糊精（α-CD）与这两个片段添加在一起时，Alg-β-CD/mPEG-Fc/α-CD的稳定非共价超分子结构可在水溶液中自组装成纳米粒子。还制备了负载BSA的Alg-β-CD/mPEG-Fc/α-CD。有趣的是，这些超分子Alg-β-CD/mPEG-Fc/α-CD/BSA纳米粒子呈现出均匀的球形结构和恒定的BSA负载量。此外，这种新型纳米粒子在过氧化氢（HO）存在下会分解。由于葡萄糖氧化酶（GOD）可氧化葡萄糖并产生HO，因此这种聚合物纳米粒子在含有GOD的环境中也可具有葡萄糖响应行为。所开发的功能性Alg-β-CD/mPEG-Fc/α-CD可能是一种更高效的糖尿病或免疫治疗药物递送策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cb/5985298/777ef6c0baca/fphar-09-00552-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cb/5985298/ed5f33f6fa5c/fphar-09-00552-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cb/5985298/a101f7bf22a3/fphar-09-00552-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cb/5985298/d3b3f7c6712c/fphar-09-00552-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cb/5985298/5d61864e9527/fphar-09-00552-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cb/5985298/5494ba442157/fphar-09-00552-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cb/5985298/777ef6c0baca/fphar-09-00552-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cb/5985298/ed5f33f6fa5c/fphar-09-00552-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cb/5985298/a101f7bf22a3/fphar-09-00552-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cb/5985298/d3b3f7c6712c/fphar-09-00552-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cb/5985298/5d61864e9527/fphar-09-00552-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cb/5985298/5494ba442157/fphar-09-00552-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cb/5985298/777ef6c0baca/fphar-09-00552-g008.jpg

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