文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

浸渍草药油的特性。

Properties of macerated herbal oil.

作者信息

Kantawong Fahsai, Singhatong Supawatchara, Srilamay Aomjai, Boonyuen Kantarose, Mooti Niroot, Wanachantararak Phenphichar, Kuboki Thasaneeya

机构信息

Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.

The Dental Research Center, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand.

出版信息

Bioimpacts. 2017;7(1):13-23. doi: 10.15171/bi.2017.03. Epub 2017 Feb 8.

DOI:10.15171/bi.2017.03
PMID:28546949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5439385/
Abstract

The addition of herbs into hot sesame oil could increase the oil-pulling efficiency of sesame oil. The aim of present study was to modify the proportion of herbs and sesame oil with the addition of other ingredients including menthol, camphor, and borneol and improve the medicinal properties and the scent of the oil. Macerated herbal oil was prepared by heat extraction of five species of herbs ( Linn and ) with hot sesame oil. The study was performed to evaluate the anti-oxidant, anti-inflammatory, and anti-bacterial properties of this macerated herbal oil. Macerated herbal oil was evaluated for antioxidant activity using DPPH and ABTS assays. It was shown that at dilution 1:2 in DMSO, the macerated herbal oil had DPPH and ABTS radical scavenging activities equal to 63% and 22%, respectively. Macerated herbal oil dilution 1:8 in DMSO demonstrated ferric reducing capacity equivalent to ascorbic acid (0.208 µM) and had reducing power equivalent to (BHT) 7.41 µg/mL. MTT assay was performed using immortalized human mesenchymal stem cells (HMSCs) as a cell culture model. The result indicated that the cytotoxic concentration of the macerated herbal oil was ≥ 2.5 µL/mL in complete DMEM. Anti-inflammatory effects were evaluated using the nitrite assay and RT-PCR. It was found that the macerated herbal oil could inhibit nitrite accumulation in culture media. Change in the expression of COX-2, Nrf2, and NF-kB in RT-PCR confirmed the anti-inflammatory activity of the macerated herbal oil. It could be concluded that the macerated herbal oil could inhibit nitrite accumulation in culture media, which might be the inhibitory effect of the macerated herbal oil on COX-2 or Nrf2, the downstream modulator of the COX-2 pathway. Further intensive studies are needed for the optimization before bringing this macerated herbal oil into clinical application.

摘要

在热芝麻油中添加草药可以提高芝麻油的油拔效率。本研究的目的是通过添加薄荷醇、樟脑和冰片等其他成分来调整草药与芝麻油的比例，并改善油的药用特性和气味。通过用热芝麻油对五种草药（林恩和）进行热提取制备浸制草药油。进行该研究以评估这种浸制草药油的抗氧化、抗炎和抗菌特性。使用DPPH和ABTS测定法评估浸制草药油的抗氧化活性。结果表明，在二甲基亚砜中1:2稀释时，浸制草药油的DPPH和ABTS自由基清除活性分别等于63%和22%。在二甲基亚砜中1:8稀释的浸制草药油表现出与抗坏血酸（0.208 μM）相当的铁还原能力，并且具有与（丁基羟基甲苯）7.41 μg/mL相当的还原能力。使用永生化人间充质干细胞（HMSCs）作为细胞培养模型进行MTT测定。结果表明，在完全DMEM中，浸制草药油的细胞毒性浓度≥2.5 μL/mL。使用亚硝酸盐测定法和RT-PCR评估抗炎作用。发现浸制草药油可以抑制培养基中亚硝酸盐的积累。RT-PCR中COX-2、Nrf2和NF-κB表达的变化证实了浸制草药油的抗炎活性。可以得出结论，浸制草药油可以抑制培养基中亚硝酸盐的积累，这可能是浸制草药油对COX-2或COX-2途径的下游调节因子Nrf2的抑制作用。在将这种浸制草药油应用于临床之前，需要进一步深入研究以进行优化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ab5/5439385/dda73878c47b/bi-7-13-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ab5/5439385/deb3a8335d43/bi-7-13-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ab5/5439385/7fef08250714/bi-7-13-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ab5/5439385/cd8424ea2e76/bi-7-13-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ab5/5439385/9d56efd94c60/bi-7-13-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ab5/5439385/63f642d78e22/bi-7-13-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ab5/5439385/292276d718c8/bi-7-13-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ab5/5439385/da6127021a9b/bi-7-13-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ab5/5439385/dda73878c47b/bi-7-13-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ab5/5439385/deb3a8335d43/bi-7-13-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ab5/5439385/7fef08250714/bi-7-13-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ab5/5439385/cd8424ea2e76/bi-7-13-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ab5/5439385/9d56efd94c60/bi-7-13-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ab5/5439385/63f642d78e22/bi-7-13-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ab5/5439385/292276d718c8/bi-7-13-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ab5/5439385/da6127021a9b/bi-7-13-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ab5/5439385/dda73878c47b/bi-7-13-g008.jpg

相似文献

[1]
Properties of macerated herbal oil.

Bioimpacts. 2017

[2]
Variation in secondary metabolite production as well as antioxidant and antibacterial activities of Zingiber zerumbet (L.) at different stages of growth.

BMC Complement Altern Med. 2016-3-22

[3]
Spectroscopic studies on the antioxidant activity of ellagic acid.

Spectrochim Acta A Mol Biomol Spectrosc. 2014-9-15

[4]
Herbal formula SC-E1 suppresses lipopolysaccharide-stimulated inflammatory responses through activation of Nrf2/HO-1 signaling pathway in RAW 264.7 macrophages.

BMC Complement Altern Med. 2017-7-28

[5]
Synthesis and in vitro Antioxidant Activity Study of Some Novel Substituted Piperazinyl Flavone Compounds.

Med Chem. 2018

[6]
Polarity of extracts and fractions of four Combretum (Combretaceae) species used to treat infections and gastrointestinal disorders in southern African traditional medicine has a major effect on different relevant in vitro activities.

J Ethnopharmacol. 2014-6-11

[7]
Antioxidative activities and the total phenolic contents of tonic Chinese medicinal herbs.

Inflammopharmacology. 2008-10

[8]
Chemical composition, anti-toxoplasma, cytotoxicity, antioxidant, and anti-inflammatory potentials of Cola gigantea seed oil.

Pharm Biol. 2019-12

[9]
Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis.

Pharmacol Res. 2002-6

[10]
Comparison of in vitro antioxidant and antiradical activities of L-tyrosine and L-Dopa.

Amino Acids. 2007

引用本文的文献

[1]
Transforming Medicinal Oil into Advanced Gel: An Update on Advancements.

Gels. 2024-5-17

[2]
A Comparative Analysis of Phenolic Content, Antioxidant Activity, Antimicrobial Activity, and Chemical Profile of Extracts Using Subcritical Fluid Extraction and Supercritical Carbon Dioxide Extraction.

Foods. 2023-9-15

[3]
Antibacterial efficacy of (makrut lime) essential oil against clinical multidrug-resistant methicillin-resistant and methicillin-susceptible isolates.

Saudi Pharm J. 2023-6

[4]
Herbal Additives Substantially Modify Antioxidant Properties and Tocopherol Content of Cold-Pressed Oils.

Antioxidants (Basel). 2021-5-14

本文引用的文献

[1]
Geno/cytotoxicty and Apoptotic Properties of Phenolic Compounds from the Seeds of Dorema Glabrum Fisch. C.A.

Bioimpacts. 2014-12-30

[2]
Therapeutic effects of sesame oil on monosodium urate crystal-induced acute inflammatory response in rats.

Springerplus. 2013-12-7

[3]
Anti-inflammatory and immunomodulatory mechanisms of mesenchymal stem cell transplantation in experimental traumatic brain injury.

J Neuroinflammation. 2013-8-23

[4]
Human bone marrow-derived mesenchymal stem cell gene expression patterns vary with culture conditions.

Blood Res. 2013-6

[5]
Roles nrf2 plays in myeloid cells and related disorders.

Oxid Med Cell Longev. 2013-6-2

[6]
Sesame oil therapeutically ameliorates cardiac hypertrophy by regulating hypokalemia in hypertensive rats.

JPEN J Parenter Enteral Nutr. 2014-8

[7]
Osteoprotective effect of soybean and sesame oils in ovariectomized rats via estrogen-like mechanism.

Cytotechnology. 2013-6-8

[8]
Sesame oil attenuates ovalbumin-induced pulmonary edema and bronchial neutrophilic inflammation in mice.

Biomed Res Int. 2013-4-4

[9]
Antimicrobial activities of the rhizome extract of Zingiber zerumbet Linn.

Asian Pac J Trop Biomed. 2011-10

[10]
Evaluation of Plantago major L. seed mucilage as a rate controlling matrix for sustained release of propranolol hydrochloride.

Acta Pharm. 2013-3

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索