Huang Weihua, Ling Qihua, Jarvis Paul
Department of Biology; University of Leicester; Leicester, UK.
Commun Integr Biol. 2013 Mar 1;6(2):e23001. doi: 10.4161/cib.23001.
In a recently published work, we identified the first chloroplast-localized E3 ligase, and showed that it degrades TOC translocon proteins by the ubiquitin-proteasome system (UPS). This regulation was found to be critical for plastid developmental transitions, such as the conversion of etioplasts to chloroplasts. Here we discuss the importance of SP1 for plants under different circumstances, and speculate about SP1 function and its possible application in agriculture. We anticipate that further work in this area may reveal additional roles of the UPS system, through action on other chloroplast OEPs with different roles in plastid biogenesis and function.
在最近发表的一项研究中，我们鉴定出首个定位于叶绿体的E3连接酶，并表明它通过泛素-蛋白酶体系统（UPS）降解TOC转位蛋白。发现这种调节对于质体发育转变至关重要，例如黄化质体向叶绿体的转变。在此，我们讨论了SP1在不同情况下对植物的重要性，并推测了SP1的功能及其在农业中的可能应用。我们预计，该领域的进一步研究可能会揭示UPS系统的其他作用，这是通过作用于在质体生物发生和功能中具有不同作用的其他叶绿体外被蛋白实现的。
