Avci Pinar, Nyame Theodore T, Gupta Gaurav K, Sadasivam Magesh, Hamblin Michael R
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Lasers Surg Med. 2013 Aug;45(6):349-57. doi: 10.1002/lsm.22153. Epub 2013 Jun 7.
Low-level laser (light) therapy (LLLT) is a noninvasive, nonthermal approach to disorders requiring reduction of pain and inflammation and stimulation of healing and tissue regeneration. Within the last decade, LLLT started being investigated as an adjuvant to liposuction, for noninvasive body contouring, reduction of cellulite, and improvement of blood lipid profile. LLLT may also aid autologous fat transfer procedures by enhancing the viability of adipocytes. However the underlying mechanism of actions for such effects still seems to be unclear. It is important, therefore, to understand the potential efficacy and proposed mechanism of actions of this new procedure for fat reduction.
A review of the literature associated with applications of LLLT related to fat layer reduction was performed to evaluate the findings from pre-clinical and clinical studies with respect to the mechanism of action, efficacy, and safety.
The studies as of today suggest that LLLT has a potential to be used in fat and cellulite reduction as well as in improvement of blood lipid profile without any significant side effects. One of the main proposed mechanism of actions is based upon production of transient pores in adipocytes, allowing lipids to leak out. Another is through activation of the complement cascade which could cause induction of adipocyte apoptosis and subsequent release of lipids.
Although the present studies have demonstrated safety and efficacy of LLLT in fat layer reduction, studies demonstrating the efficacy of LLLT as a stand-alone procedure are still inadequate. Moreover, further studies are necessary to identify the mechanism of action.
低强度激光（光）疗法（LLLT）是一种非侵入性、非热疗的方法，用于治疗需要减轻疼痛和炎症以及促进愈合和组织再生的疾病。在过去十年中，LLLT开始被研究作为抽脂术的辅助手段，用于非侵入性身体塑形、减少橘皮组织以及改善血脂状况。LLLT还可能通过提高脂肪细胞的活力来辅助自体脂肪移植手术。然而，这种效应的潜在作用机制似乎仍不清楚。因此，了解这种新的减脂方法的潜在疗效和作用机制很重要。
对与LLLT在减少脂肪层应用相关的文献进行综述，以评估临床前和临床研究在作用机制、疗效和安全性方面的研究结果。
截至目前的研究表明，LLLT有潜力用于减少脂肪和橘皮组织以及改善血脂状况，且无任何明显副作用。主要提出的作用机制之一是基于在脂肪细胞中产生瞬时孔隙，使脂质泄漏出来。另一个机制是通过激活补体级联反应，这可能导致脂肪细胞凋亡的诱导以及随后脂质的释放。
尽管目前的研究已经证明了LLLT在减少脂肪层方面的安全性和有效性，但证明LLLT作为一种独立方法有效性的研究仍然不足。此外，还需要进一步研究来确定其作用机制。
