Nestor Mark S, Newburger Jessica, Zarraga Matthew B
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Semin Cutan Med Surg. 2013 Mar;32(1):35-40.
Noninvasive body contouring has become one of the fastest-growing areas of esthetic medicine. Many patients appear to prefer nonsurgical less-invasive procedures owing to the benefits of fewer side effects and shorter recovery times. Increasingly, 635-nm low-level laser therapy (LLLT) has been used in the treatment of a variety of medical conditions and has been shown to improve wound healing, reduce edema, and relieve acute pain. Within the past decade, LLLT has also emerged as a new modality for noninvasive body contouring. Research has shown that LLLT is effective in reducing overall body circumference measurements of specifically treated regions, including the hips, waist, thighs, and upper arms, with recent studies demonstrating the long-term effectiveness of results. The treatment is painless, and there appears to be no adverse events associated with LLLT. The mechanism of action of LLLT in body contouring is believed to stem from photoactivation of cytochrome c oxidase within hypertrophic adipocytes, which, in turn, affects intracellular secondary cascades, resulting in the formation of transitory pores within the adipocytes' membrane. The secondary cascades involved may include, but are not limited to, activation of cytosolic lipase and nitric oxide. Newly formed pores release intracellular lipids, which are further metabolized. Future studies need to fully outline the cellular and systemic effects of LLLT as well as determine optimal treatment protocols.
非侵入性身体塑形已成为美容医学中发展最快的领域之一。由于副作用较少且恢复时间较短，许多患者似乎更喜欢非手术的微创治疗方法。635纳米低强度激光疗法（LLLT）越来越多地用于治疗各种医疗状况，并已被证明可促进伤口愈合、减轻水肿和缓解急性疼痛。在过去十年中，LLLT也已成为非侵入性身体塑形的一种新方式。研究表明，LLLT可有效减少特定治疗部位的全身周长，包括臀部、腰部、大腿和上臂，最近的研究证明了其效果的长期有效性。该治疗无痛，且似乎没有与LLLT相关的不良事件。LLLT在身体塑形中的作用机制被认为源于肥大脂肪细胞内细胞色素c氧化酶的光激活，这反过来又影响细胞内二级级联反应，导致脂肪细胞膜内形成瞬时孔道。涉及的二级级联反应可能包括但不限于胞质脂肪酶和一氧化氮的激活。新形成的孔道释放细胞内脂质，这些脂质会进一步代谢。未来的研究需要全面概述LLLT的细胞和全身效应，并确定最佳治疗方案。
