Department of Medicine, Medical and Health Science Center, University of Debrecen, H-4032 Debrecen Nagyerdei krt. 98, Hungary.
Database (Oxford). 2013 Jun 11;2013:bat037. doi: 10.1093/database/bat037. Print 2013.
Adaptation to different types of environmental stress is a common part of life for today's fungi. A deeper understanding of the organization, regulation and evolution of fungal stress response systems may lead to the development of novel antifungal drugs and technologies or the engineering of industrial strains with elevated stress tolerance. Here we present the Fungal Stress Response Database (http://internal.med.unideb.hu/fsrd) aimed to stimulate further research on stress biology of fungi. The database incorporates 1985 fungal stress response proteins with verified physiological function(s) and their orthologs identified and annotated in 28 species including human and plant pathogens, as well as important industrial fungi. The database will be extended continuously to cover other fully sequenced fungal species. Our database, as a starting point for future stress research, facilitates the analysis of literature data on stress and the identification of ortholog groups of stress response proteins in newly sequenced fungal genomes. Database URL: http://internal.med.unideb.hu/fsrd
适应不同类型的环境压力是当今真菌生活的常见部分。更深入地了解真菌应激反应系统的组织、调节和进化，可能会导致新型抗真菌药物和技术的开发，或者提高工业菌株的应激耐受性的工程设计。在这里，我们展示了真菌应激反应数据库（http://internal.med.unideb.hu/fsrd），旨在激发对真菌应激生物学的进一步研究。该数据库包含了 1985 种具有已验证生理功能的真菌应激反应蛋白，以及在 28 个物种（包括人类和植物病原体以及重要的工业真菌）中鉴定和注释的其同源物。该数据库将不断扩展，以涵盖其他全序列真菌物种。我们的数据库作为未来应激研究的起点，为分析应激相关文献数据以及鉴定新测序真菌基因组中应激反应蛋白的同源物组提供了便利。数据库网址：http://internal.med.unideb.hu/fsrd
