Department of Nephrology, University Medical Center Groningen, Sector A, PO Box 30.001, 9700 RB Groningen, The Netherlands.
Clin Transplant. 2013 Jul-Aug;27(4):E484-90. doi: 10.1111/ctr.12149. Epub 2013 Jun 13.
Long-term survival of renal transplant recipients (RTR) has not improved over the past 20 yr. The question rises to what extent lifestyle factors play a role in post-transplant weight gain and its associated risks after transplantation.
Twenty-six RTR were measured for body weight, body composition, blood lipids, renal function, dietary intake, and physical activity at six wk, and three, six, and 12 months after transplantation.
Weight gain ranged between -2.4 kg and 19.5 kg and was largely due to increase in body fat. RTR who remained body fat stable, showed more daily physical activity (p = 0.014), tended to consume less energy from drinks and dairy (p = 0.054), consumed less mono- and disaccharides (sugars) (p = 0.021) and ate more vegetables (p = 0.043) compared with those who gained body fat. Gain in body fat was strongly related to total cholesterol (r = 0.46, p = 0.017) and triglyceride (r = 0.511, p = 0.011) at one yr after transplantation.
Gain in adiposity after renal transplantation is related to lifestyle factors such as high consumption of energy-rich drinks, high intake of mono- and disaccharides and low daily physical activity. RCTs are needed to investigate potential benefits of lifestyle intervention on long-term morbidity and mortality.
在过去的 20 年中，肾移植受者（RTR）的长期存活率并未提高。问题是，生活方式因素在多大程度上影响移植后体重增加及其相关风险。
在移植后 6 周、3 个月、6 个月和 12 个月时，对 26 名 RTR 进行体重、身体成分、血脂、肾功能、饮食摄入和体力活动测量。
体重增加范围为-2.4 公斤至 19.5 公斤，主要是由于体脂增加。与体脂稳定的 RTR 相比，体脂增加的 RTR 每天的体力活动更多（p=0.014），倾向于减少饮料和乳制品（p=0.054）、单糖和二糖（糖）（p=0.021）的摄入，并多吃蔬菜（p=0.043）。体脂增加与移植后 1 年的总胆固醇（r=0.46，p=0.017）和甘油三酯（r=0.511，p=0.011）密切相关。
肾移植后脂肪量增加与生活方式因素有关，如能量饮料摄入过多、单糖和二糖摄入过多以及日常体力活动不足。需要进行 RCT 来研究生活方式干预对长期发病率和死亡率的潜在益处。
