Keithley E M, Krekorian T D, Sharp P A, Harris J P, Ryan A F
Division of Otolaryngology, University of California San Diego Medical School.
Eur Arch Otorhinolaryngol. 1990;247(4):247-51. doi: 10.1007/BF00178996.
The distribution of immunoglobulin-bearing cells and the pattern of histopathological changes in the middle ear (ME) mucosa, round window membrane (RWM), and inner ear were compared during acute and chronic immune-mediated otitis media with effusion (OME) in the guinea pig as an animal model. In both acute and chronic immune responses (IRs), mucosal hyperplasia, edema, neovascularization, and cellular infiltration were observed. IgG+ cells were predominant in both the acute and chronic IRs. The number of IgA+ cells, however, increased in the mucosa and RWM during chronic IRs. Only the chronic IR resulted in gland formation within the ME and inflammation within the cochlea. These results indicate that the chronic IR was more similar to reports of clinical OME than the acute IR. The cochlear inflammation associated with chronic OME can lead to sensorineural hearing loss, as reported in clinical studies.
以豚鼠为动物模型，比较了急性和慢性免疫介导的分泌性中耳炎（OME）期间中耳（ME）黏膜、圆窗膜（RWM）和内耳中携带免疫球蛋白细胞的分布以及组织病理学变化模式。在急性和慢性免疫反应（IR）中，均观察到黏膜增生、水肿、新生血管形成和细胞浸润。IgG⁺细胞在急性和慢性IR中均占主导地位。然而，在慢性IR期间，黏膜和RWM中IgA⁺细胞的数量增加。只有慢性IR导致中耳内腺体形成和耳蜗内炎症。这些结果表明，慢性IR比急性IR更类似于临床OME的报道。如临床研究中所报道的，与慢性OME相关的耳蜗炎症可导致感音神经性听力损失。
