Jeong Hyun-Ja, Hong Seung-Heon, Kim Sung-Chul, Park Eun-Jeong, Jang Chul-Ho, Kim Kyung-Suk, Kim Hyung-Min
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk, Republic of Korea.
Inflammation. 2002 Apr;26(2):89-95. doi: 10.1023/a:1014888328482.
The number of pediatric patients with recurrent otitis media with effusions (ROMEs) is increasing because of the frequency of recurrence. The herbal combination Allergina is used for inflammatory-disease treatment in the Republic of Korea; in our study, the patients with ROME were treated with either Allergina (11 ears) or antibiotics (13 ears). We analyzed the levels of cytokines in middle-ear effusions (MEEs) and compared these levels in the Allergina-treated patients with those in the antibiotics-treated patients. The mean levels of interleukin (IL)-2 and IL-4 in MEEs were significantly higher in the Allergina-treated patients than in the antibiotics-treated patients, whereas levels of IL-1beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha in MEEs were significantly lower in the Allergina-treated patients than in the antibiotics-treated patients. Clinical signs of ROME disappeared markedly after all the patients were given an oral administration of Allergina. Our experimental studies provide evidence that Allergina may be beneficial in the treatment of ROME by regulating cytokine production.
由于复发频率，复发性中耳炎伴积液（ROME）的儿科患者数量正在增加。草药组合Allergina在韩国用于治疗炎症性疾病；在我们的研究中，ROME患者分别接受Allergina治疗（11耳）或抗生素治疗（13耳）。我们分析了中耳积液（MEE）中的细胞因子水平，并比较了Allergina治疗患者与抗生素治疗患者的这些水平。Allergina治疗患者的MEE中白细胞介素（IL）-2和IL-4的平均水平显著高于抗生素治疗患者，而Allergina治疗患者的MEE中IL-1β、IL-6、IL-8和肿瘤坏死因子（TNF）-α的水平显著低于抗生素治疗患者。在所有患者口服Allergina后，ROME的临床症状明显消失。我们的实验研究提供了证据，表明Allergina可能通过调节细胞因子产生对ROME治疗有益。
