Shen Yongchun, Guo Shujin, Yang Ting, Jia Liuqun, Chen Lei, An Jing, Wang Tao, Wen Fuqiang
Division of Internal Medicine, West China Hospital of Sichuan University, Chengdu 610041, China.
Int J Mol Sci. 2013 May 28;14(6):11392-401. doi: 10.3390/ijms140611392.
The -173 G/C polymorphism in the macrophage migration inhibitory factor (MIF) gene has been implicated in susceptibility to inflammatory bowel disease (IBD), but the results are inconclusive. The present meta-analysis aimed to investigate the overall association between the -173 G/C polymorphism and IBD risk. We searched in Pubmed, and Embase for studies evaluating the association between the -173G/C gene polymorphism and IBD risk. Data were extracted and statistical analysis was performed using Revman 5.1 and STATA 12.0 software. A total of seven publications involving 4729 subjects (2282 IBD cases and 2447 controls) were included in this meta-analysis. Combined analysis revealed a clear association between this polymorphism and IBD susceptibility (OR = 1.48, 95% CI: 1.10-2.00, p = 0.009 for CC vs. CG + GG). Subgroup analysis by ethnicity showed that the IBD risk associated with the -173G/C gene polymorphism was significantly elevated among Asians (OR = 1.79, 95% CI: 1.08-2.96, p = 0.02), but not among Caucasians. Subgroup analysis by disease suggested that the -173G/C gene polymorphism is a risk factor for ulcerative colitis (OR = 1.62, 95% CI: 1.10-2.37, p = 0.01), but that it was not associated with Crohn's disease. This meta-analysis suggests that the -173 G/C polymorphism in the macrophage MIF gene contributes to IBD susceptibility, specifically in Asian populations. Further studies are needed to validate these findings.
巨噬细胞移动抑制因子（MIF）基因 -173G/C 多态性与炎症性肠病（IBD）易感性有关，但结果尚无定论。本荟萃分析旨在研究 -173G/C 多态性与 IBD 风险之间的总体关联。我们在 Pubmed 和 Embase 中检索评估 -173G/C 基因多态性与 IBD 风险关联的研究。使用 Revman 5.1 和 STATA 12.0 软件提取数据并进行统计分析。本荟萃分析共纳入 7 篇文献，涉及 4729 名受试者（2282 例 IBD 病例和 2447 名对照）。合并分析显示该多态性与 IBD 易感性之间存在明显关联（CC 与 CG + GG 相比，OR = 1.48，95%CI：1.10 - 2.00，p = 0.009）。按种族进行的亚组分析表明，-173G/C 基因多态性相关的 IBD 风险在亚洲人中显著升高（OR = 1.79，95%CI：1.08 - 2.96，p = 0.02），而在白种人中未升高。按疾病进行的亚组分析表明，-173G/C 基因多态性是溃疡性结肠炎的危险因素（OR = 1.62，95%CI：1.10 - 2.37，p = 0.01），但与克罗恩病无关。本荟萃分析表明，巨噬细胞 MIF 基因的 -173G/C 多态性与 IBD 易感性有关，特别是在亚洲人群中。需要进一步研究来验证这些发现。
