Jackson R, Stewart A, Beaglehole R
Department of Community Health, School of Medicine, University of Auckland, New Zealand.
Int J Epidemiol. 1990 Jun;19(2):279-83. doi: 10.1093/ije/19.2.279.
Routine mortality statistics show that coronary heart disease (CHD) death rates have declined consistently in Auckland men since 1968; in women, death rates declined between 1968 and 1986 but since 1981 there may have been a reduction in the rate of decline. Data from CHD registers conducted in Auckland, New Zealand in 1974, 1981, and since 1983 as part of the WHO MONICA Project, have been used to investigate the validity and reasons for the decline in the age group 35-64 years. In Auckland age-standardized sudden coronary death rates in men declined by approximately 2% per year between 1974 and 1986; there was no apparent decline in women. There was also an indication of a decline in age-standardized definite myocardial infarction rates but again only in men; 28 day case fatality in patients with a definite myocardial infarction has not changed significantly in the period 1981-1986. These results validate the mortality trends based on death certificates and in particular the differing recent trends in men and women. The decline in CHD mortality in men without a concomitant change in case fatality and the lack of recent decline in women, suggest that changes in the natural history of the disease rather than treatment are responsible for the mortality trends. Since disease events are rare in absolute numbers, long-term monitoring of coronary heart disease in large population groups will be necessary to usefully study disease trends, particularly in women.
常规死亡率统计数据显示,自1968年以来,奥克兰男性的冠心病(CHD)死亡率持续下降;女性的死亡率在1968年至1986年间有所下降,但自1981年以来,下降速度可能有所减缓。作为世界卫生组织MONICA项目的一部分,1974年、1981年以及自1983年以来在新西兰奥克兰进行的冠心病登记数据,已被用于调查35至64岁年龄组死亡率下降的有效性及原因。在奥克兰,1974年至1986年间男性年龄标准化的冠心病猝死率每年下降约2%;女性则没有明显下降。年龄标准化的明确心肌梗死发生率也有下降的迹象,但同样仅在男性中出现;1981年至1986年期间,明确心肌梗死患者的28天病死率没有显著变化。这些结果证实了基于死亡证明的死亡率趋势,尤其是近期男性和女性的不同趋势。男性冠心病死亡率下降而病死率没有相应变化,以及女性近期缺乏下降趋势,表明疾病自然史的变化而非治疗是死亡率趋势的原因。由于疾病事件的绝对数量很少,有必要对大量人群进行冠心病的长期监测,以便有效地研究疾病趋势,特别是在女性中。