通过转录组测序对人类循环中的病毒进行分类和发现。
Viral categorization and discovery in human circulation by transcriptome sequencing.
机构信息
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.
出版信息
Biochem Biophys Res Commun. 2013 Jul 5;436(3):525-9. doi: 10.1016/j.bbrc.2013.05.139. Epub 2013 Jun 11.
Abstract
Serum is the most common and easily accessible patient specimen in a minimally invasive manner. As a biological resource, RNA in serum has been less explored for its clinical utilization due to prevailing concerns regarding its high degradable nature. In the current study, however, we have documented the use of human serum RNA for viral categorization and discovery through transcriptome sequencing and analysis using well-curated databases and advanced bioinformatic tools. Such an integrated approach may have an immediate application in any clinical situations concerning with viral etiology.
摘要
血清是最常见且最容易通过微创方式获得的患者样本。作为一种生物资源，由于人们普遍担心其高度可降解性，血清中的 RNA 在临床应用方面的研究较少。然而，在本研究中，我们通过使用精心整理的数据库和先进的生物信息学工具进行转录组测序和分析，记录了使用人类血清 RNA 进行病毒分类和发现的情况。这种综合方法可能会立即应用于任何涉及病毒病因的临床情况。
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