Beijing Key Laboratory of Agricultural Product Detection and Control of Spoilage Organisms and Pesticide Residue, College of Food Science and Engineering, Beijing University of Agriculture, 11 Beinong Road, Changping District, Beijing 102206, China.
Food Funct. 2013 Aug;4(8):1245-51. doi: 10.1039/c3fo30284a.
It was previously found that soybean protein hydrolysates (SPHs) can bind with calcium to form soluble complexes and promote calcium uptake by Caco-2 cells. However, the role of SPHs-calcium complexes on bone mass still needs to be explored. Fast growing male and female rats (n = 72) were assigned to eight groups: Control, lactic acid calcium (LCa), SPHs-calcium complexes (SPHCa) and casein phosphopeptides calcium (CPPCa). After four weeks treatment, oral administration of SPHCa significantly increased femur BMD of rats compared with Control and LCa groups (P < 0.05), while there are no obvious difference on the BMD of femur and lumbar vertebrae between SPHCa and CPPCa groups. Also, SPHCa showed a tendency to improve the mechanical properties of vertebra lumber for female rats. These findings suggest that the SPHs-calcium complexes might have positive effects on bone accretion of fast growing animals. This study brings new insight for better understanding the role of soybean protein itself on bone mass.
先前的研究发现，大豆蛋白水解物（SPH）可以与钙结合形成可溶性复合物，促进 Caco-2 细胞对钙的吸收。然而，SPH-钙复合物在骨量中的作用仍需要进一步探索。本研究将快速生长的雄性和雌性大鼠（n = 72）分为 8 组：对照组、乳酸钙（LCa）组、SPH-钙复合物（SPHCa）组和酪蛋白磷酸肽钙（CPPCa）组。四周的处理后，与对照组和 LCa 组相比，SPHCa 组的大鼠股骨骨密度明显增加（P < 0.05），而 SPHCa 组与 CPPCa 组之间的股骨和腰椎骨密度无明显差异。此外，SPHCa 对雌性大鼠腰椎的力学性能有改善趋势。这些发现表明，SPH-钙复合物可能对快速生长动物的骨沉积有积极作用。本研究为更好地理解大豆蛋白本身对骨量的作用提供了新的见解。
