Xu Zhe, Han Shiying, Chen Hui, Zhu Zhixuan, Han Lingyu, Dong Xiufang, Du Ming, Li Tingting
Key Laboratory of Biotechnology and Bioresources Utilization, College of Life Sciences, Dalian Minzu University, Ministry of Education, Dalian, China.
Key Laboratory of Marine Fishery Resources Exploitment and Utilization of Zhejiang Province, College of Food Science and Technology, Zhejiang University of Technology, Hangzhou, China.
Front Nutr. 2022 Apr 5;9:840638. doi: 10.3389/fnut.2022.840638. eCollection 2022.
In a previous study, the peptide LGKDQVRT, which was identified by enzymatic hydrolysis, released during the proteolysis of , had potential osteogenic activity. In this study, the octapeptide LGKDQVRT was able to spontaneously bind calcium in a 1:1 stoichiometric ratio, and the calcium-binding site likely involves calcium and amino acid VAL6 in the LGKDQVRT peptide to form a metal-donor to metal acceptor complex. The peptide LGKDQVRT has the activity of promoting the proliferation and differentiation of osteoblasts. The results of this study suggest that hydrolyzed peptides from protein can be used as a dietary supplement to improve calcium absorption and prevent osteoporosis.
在先前的一项研究中，通过酶促水解鉴定出的肽LGKDQVRT，在 蛋白的蛋白水解过程中释放出来，具有潜在的成骨活性。在本研究中，八肽LGKDQVRT能够以1:1的化学计量比自发结合钙，钙结合位点可能涉及LGKDQVRT肽中的钙和氨基酸VAL6，形成金属供体到金属受体的复合物。肽LGKDQVRT具有促进成骨细胞增殖和分化的活性。本研究结果表明，来自 蛋白的水解肽可作为膳食补充剂，以改善钙吸收并预防骨质疏松症。
