一种衍生的成骨肽对钙的螯合及吸收特性

Characterization of Chelation and Absorption of Calcium by a Derived Osteogenic Peptide.

作者信息

Xu Zhe, Han Shiying, Chen Hui, Zhu Zhixuan, Han Lingyu, Dong Xiufang, Du Ming, Li Tingting

机构信息

Key Laboratory of Biotechnology and Bioresources Utilization, College of Life Sciences, Dalian Minzu University, Ministry of Education, Dalian, China.

Key Laboratory of Marine Fishery Resources Exploitment and Utilization of Zhejiang Province, College of Food Science and Technology, Zhejiang University of Technology, Hangzhou, China.

出版信息

Front Nutr. 2022 Apr 5;9:840638. doi: 10.3389/fnut.2022.840638. eCollection 2022.

In a previous study, the peptide LGKDQVRT, which was identified by enzymatic hydrolysis, released during the proteolysis of , had potential osteogenic activity. In this study, the octapeptide LGKDQVRT was able to spontaneously bind calcium in a 1:1 stoichiometric ratio, and the calcium-binding site likely involves calcium and amino acid VAL6 in the LGKDQVRT peptide to form a metal-donor to metal acceptor complex. The peptide LGKDQVRT has the activity of promoting the proliferation and differentiation of osteoblasts. The results of this study suggest that hydrolyzed peptides from protein can be used as a dietary supplement to improve calcium absorption and prevent osteoporosis.