Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto, 607-8414, Japan,
Dig Dis Sci. 2013 Oct;58(10):2840-9. doi: 10.1007/s10620-013-2725-7. Epub 2013 Jun 14.
BACKGROUND/AIMS: The effects of feeding conditions (fasted or fed) and dietary fiber (DF) in the diet on gastrointestinal (GI) damage induced by aspirin (ASA) were examined in cats.
Plain ASA (P-ASA, 20 mg/kg) or one enteric-coated ASA tablet (EC-ASA, containing 100 mg ASA) was administered p.o. once daily for 3 or 7 days just after morning meal, 3 h after the evening meal, or in the morning without a morning meal (fasted). Several types of diet, dry food (DRY, DF: 2.8 %), canned food (CAN, DF: 0.4 %), and diets with added cellulose or pectin were provided twice daily.
P-ASA or EC-ASA administered just after feeding of DRY caused marked lesions in the GI tract, although EC-ASA did not produce any lesions in the stomach. GI damage was markedly decreased when ASA was administered 3 h after the evening meal. The induction of lesions by EC-ASA was markedly decreased in cats that ate CAN, but lesions were induced in cats fed CAN with added cellulose (6 %). The addition of pectin (6 %) to the DRY markedly decreased the induction of lesions by EC-ASA.
The results indicate that the induction of GI lesions by ASA was highly dependent on the feeding conditions and DF. To minimize the induction of GI damage, it would be better to take ASA 3 h after the evening meal, or after consuming diets that contain low amounts of insoluble DF and high amounts of soluble DF.
背景/目的：本研究旨在探讨进食条件（禁食或进食）和饮食纤维（DF）对猫阿司匹林（ASA）诱导的胃肠道（GI）损伤的影响。
猫每日口服 plain ASA（P-ASA，20 mg/kg）或 one enteric-coated ASA 片剂（EC-ASA，含 100 mg ASA）一次，连续 3 或 7 天。给药时间分别为早饭后、晚饭后 3 小时或清晨未进食（禁食）。提供了几种类型的饮食，包括干粮（DRY，DF：2.8%）、罐头食品（CAN，DF：0.4%）以及添加纤维素或果胶的饮食，每日两次。
P-ASA 或 EC-ASA 在喂食 DRY 后立即给药会导致 GI 道明显损伤，尽管 EC-ASA 不会在胃中引起任何损伤。当 ASA 在晚饭后 3 小时给药时，GI 损伤明显减少。当猫食用 CAN 时，EC-ASA 引起的损伤明显减少，但当猫食用添加纤维素（6%）的 CAN 时，仍会引起损伤。在 DRY 中添加果胶（6%）可显著减少 EC-ASA 诱导的损伤。
结果表明，ASA 诱导的 GI 损伤高度依赖于进食条件和 DF。为了最大程度地减少 GI 损伤的发生，最好在晚饭后 3 小时或在食用低不溶性 DF 和高可溶性 DF 的饮食后服用 ASA。
