Computational Biology Center, Memorial Sloan-Kettering Cancer Center, NY 10065, USA.
Bioinformatics. 2013 Aug 15;29(16):2071-2. doi: 10.1093/bioinformatics/btt345. Epub 2013 Jun 12.
The interaction between drugs and their targets, often proteins, and between antibodies and their targets, is important for planning and analyzing investigational and therapeutic interventions in many biological systems. Although drug-target and antibody-target datasets are available in separate databases, they are not publicly available in an integrated bioinformatics resource. As medical therapeutics, especially in cancer, increasingly uses targeted drugs and measures their effects on biomolecular profiles, there is an unmet need for a user-friendly toolset that allows researchers to comprehensively and conveniently access and query information about drugs, antibodies and their targets.
The PiHelper framework integrates human drug-target and antibody-target associations from publicly available resources to help meet the needs of researchers in systems pharmacology, perturbation biology and proteomics. PiHelper has utilities to (i) import drug- and antibody-target information; (ii) search the associations either programmatically or through a web user interface (UI); (iii) visualize the data interactively in a network; and (iv) export relationships for use in publications or other analysis tools.
PiHelper is a free software under the GNU Lesser General Public License (LGPL) v3.0. Source code and documentation are at http://bit.ly/pihelper. We plan to coordinate contributions from the community by managing future releases.
药物与其靶点（通常是蛋白质）之间的相互作用，以及抗体与其靶点之间的相互作用，对于规划和分析许多生物系统中的研究性和治疗性干预措施非常重要。尽管药物-靶点和抗体-靶点数据集分别存在于不同的数据库中，但它们并未在一个集成的生物信息学资源中公开提供。随着医疗疗法，尤其是癌症治疗，越来越多地使用靶向药物并测量它们对生物分子谱的影响，人们迫切需要一个用户友好的工具集，使研究人员能够全面、方便地访问和查询有关药物、抗体及其靶点的信息。
PiHelper 框架整合了来自公开资源的人类药物-靶点和抗体-靶点关联，以帮助满足系统药理学、扰动生物学和蛋白质组学研究人员的需求。PiHelper 具有以下功能：(i) 导入药物和抗体-靶点信息；(ii) 通过编程或通过网络用户界面 (UI) 搜索关联；(iii) 以交互方式在网络中可视化数据；(iv) 导出关系，以便在出版物或其他分析工具中使用。
PiHelper 是一个根据 GNU Lesser General Public License (LGPL) v3.0 发布的免费软件。源代码和文档可在 http://bit.ly/pihelper 上获得。我们计划通过管理未来的版本来协调社区的贡献。
