Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Bioinformatics. 2009 Nov 1;25(21):2860-2. doi: 10.1093/bioinformatics/btp453. Epub 2009 Jul 23.
We have developed PathBuilder, an open-source web application to annotate biological information pertaining to signaling pathways and to create web-based pathway resources. PathBuilder enables annotation of molecular events including protein-protein interactions, enzyme-substrate relationships and protein translocation events either manually or through automated importing of data from other databases. Salient features of PathBuilder include automatic validation of data formats, built-in modules for visualization of pathways, automated import of data from other pathway resources, export of data in several standard data exchange formats and an application programming interface for retrieving existing pathway datasets.
PathBuilder is freely available for download at http://pathbuilder.sourceforge.net/ under the terms of GNU lesser general public license (LGPL: http://www.gnu.org/copyleft/lesser.html). The software is platform independent and has been tested on Windows and Linux platforms.
Supplementary data are available at Bioinformatics online.
我们开发了一个开源的网络应用程序 PathBuilder，用于注释与信号通路相关的生物信息，并创建基于网络的通路资源。PathBuilder 允许通过手动或从其他数据库自动导入数据的方式注释分子事件，包括蛋白质-蛋白质相互作用、酶-底物关系和蛋白质易位事件。PathBuilder 的突出特点包括数据格式的自动验证、通路可视化的内置模块、来自其他通路资源的数据的自动导入、以多种标准数据交换格式导出数据以及用于检索现有通路数据集的应用程序编程接口。
PathBuilder 可根据 GNU 较宽松通用公共许可证（LGPL：http://www.gnu.org/copyleft/lesser.html）的条款在 http://pathbuilder.sourceforge.net/ 上免费下载。该软件与平台无关，已在 Windows 和 Linux 平台上进行了测试。
补充数据可在 Bioinformatics 在线获取。
