狂犬病疫苗接种所致神经系统并发症患者及其他神经系统疾病患者体内的抗心磷脂抗体

Anticardiolipin antibodies in patients with rabies vaccination induced neurological complications and other neurological diseases.

作者信息

Chaleomchan W, Hemachudha T, Sakulramrung R, Deesomchok U

机构信息

Department of Microbiology, Chulalongkorn University Hospital, Bangkok, Thailand.

出版信息

J Neurol Sci. 1990 May;96(2-3):143-51. doi: 10.1016/0022-510x(90)90127-9.

DOI:10.1016/0022-510x(90)90127-9

PMID:2376746

Abstract

We reported the occurrence of anticardiolipin antibodies (ACA) by using an enzyme-linked immunosorbent assay (ELISA) in sera of patients with neurologic complications from Semple rabies vaccination. There was a correlation between the presence of ACA and the disease severity. Sixteen of 25 patients (64%) with major neurological complications, 2 of 21 patients (10%) with minor complications, and non of the normal vaccinees had an ACA response. In comparison to this, ACA was found in 10/43 (24%) of patients with post-infectious encephalitis (PIE), Guillain-Barré syndrome (GBS) and multiple sclerosis (MS), 5/22 (23%) and 4/31 (13%) of patients with degenerative neurological diseases and central nervous system (CNS) infections, respectively. There was no specific restriction to any particular isotype. Frequency difference of ACA responses was unremarkable in systemic lupus erythematosus (SLE) patients with (3/9) and without (3/10) CNS involvement. It is not conclusive about the pathogenetic role of ACA. This remains to be determined.

摘要

我们通过酶联免疫吸附测定（ELISA）报告了接种森普尔狂犬病疫苗后出现神经系统并发症的患者血清中抗心磷脂抗体（ACA）的情况。ACA的存在与疾病严重程度之间存在相关性。25例有严重神经系统并发症的患者中有16例（64%）、21例有轻微并发症的患者中有2例（10%）出现了ACA反应，而正常接种疫苗者均未出现ACA反应。相比之下，感染后脑炎（PIE）、格林-巴利综合征（GBS）和多发性硬化症（MS）患者中分别有10/43（24%）、5/22（23%）和4/31（13%）的患者检测到ACA，退行性神经系统疾病和中枢神经系统（CNS）感染患者中分别有5/22（23%）和4/31（13%）检测到ACA。对任何特定的同种型均无特异性限制。系统性红斑狼疮（SLE）患者中，有中枢神经系统受累者（3/9）和无中枢神经系统受累者（3/10）的ACA反应频率差异不显著。关于ACA的致病作用尚无定论，仍有待确定。